Detailed information of TA system TA199143

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1592517..1593144
• Replicon: chromosome
• Accession: NZ_CP072902
• Organism: Bartonella henselae strain ATCC49882T var-2/ Houston-I

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0H3M2H0
• Locus tag: KAE74_RS06825
• Protein ID: WP_011180277.1
• Coordinates: 1592517..1592831 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: KAE74_RS06830
• Protein ID: WP_011180278.1
• Coordinates: 1592848..1593144 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE74_RS06805 (KAE74_06655)	1588144..1589700	-	1557	WP_011180273.1	phage portal protein	-
KAE74_RS06810 (KAE74_06660)	1589700..1589948	-	249	WP_011180274.1	hypothetical protein	-
KAE74_RS06815 (KAE74_06665)	1589952..1591880	-	1929	WP_011180275.1	phage terminase large subunit family protein	-
KAE74_RS06820 (KAE74_06670)	1591873..1592454	-	582	WP_011180276.1	hypothetical protein	-
KAE74_RS06825 (KAE74_06675)	1592517..1592831	+	315	WP_011180277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAE74_RS06830 (KAE74_06680)	1592848..1593144	+	297	WP_011180278.1	HigA family addiction module antitoxin	Antitoxin
KAE74_RS06835 (KAE74_06685)	1593554..1593817	+	264	WP_011180280.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
KAE74_RS06840 (KAE74_06690)	1593804..1594085	+	282	WP_011180281.1	type II toxin-antitoxin system YafQ family toxin	-
KAE74_RS06845 (KAE74_06695)	1594128..1594406	-	279	WP_011180242.1	hypothetical protein	-
KAE74_RS06850 (KAE74_06700)	1594403..1595161	-	759	WP_011180282.1	phage antirepressor Ant	-
KAE74_RS06855 (KAE74_06705)	1595221..1595736	-	516	WP_011180283.1	phage antirepressor Ant	-
KAE74_RS06860 (KAE74_06710)	1595753..1596592	-	840	WP_011180284.1	antA/AntB antirepressor family protein	-
KAE74_RS06865 (KAE74_06715)	1596624..1597166	-	543	WP_011180285.1	phage antirepressor Ant	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1551243..1618451	67208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (15-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12135.97 Da
• Isoelectric Point: 9.0878

>T199143 WP_011180277.1 NZ_CP072902:1592517-1592831 [Bartonella henselae]
MIHKRTNEGDLVIESFADKRCKDLLEGNPPKGFPTTLVRIVQRKLFMLDKAVDLKDLRSPPGNRLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Nucleotide

• Length: 315 bp

>T199143 NZ_CP097213:c4368879-4368706 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11262.91 Da
• Isoelectric Point: 5.8690

>AT199143 WP_011180278.1 NZ_CP072902:1592848-1593144 [Bartonella henselae]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSRITPDTALRLASFFDTTAEFWLNMQAAYDVSVL
QAEKADEFSKISKFECRV

Nucleotide

• Length: 297 bp

>AT199143 NZ_CP097213:c4369203-4368907 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A0H3M2H0