Detailed information of TA system TA199121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 742722..743349
• Replicon: chromosome
• Accession: NZ_CP072899
• Organism: Bartonella henselae strain 88-64 Oklahoma

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0H3M2H0
• Locus tag: KAE77_RS03520
• Protein ID: WP_011180277.1
• Coordinates: 743035..743349 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: KAE77_RS03515
• Protein ID: WP_011180278.1
• Coordinates: 742722..743018 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE77_RS03480 (KAE77_03440)	738700..739242	+	543	WP_011180285.1	phage antirepressor Ant	-
KAE77_RS03485 (KAE77_03445)	739274..740113	+	840	WP_011180284.1	antA/AntB antirepressor family protein	-
KAE77_RS03490 (KAE77_03450)	740130..740645	+	516	WP_011180283.1	phage antirepressor Ant	-
KAE77_RS03495 (KAE77_03455)	740705..741463	+	759	WP_011180282.1	phage antirepressor Ant	-
KAE77_RS03500 (KAE77_03460)	741460..741738	+	279	WP_011180242.1	hypothetical protein	-
KAE77_RS03505 (KAE77_03465)	741781..742062	-	282	WP_011180281.1	type II toxin-antitoxin system YafQ family toxin	-
KAE77_RS03510 (KAE77_03470)	742049..742312	-	264	WP_011180280.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
KAE77_RS03515 (KAE77_03475)	742722..743018	-	297	WP_011180278.1	HigA family addiction module antitoxin	Antitoxin
KAE77_RS03520 (KAE77_03480)	743035..743349	-	315	WP_011180277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAE77_RS03525 (KAE77_03485)	743412..743993	+	582	WP_011180276.1	hypothetical protein	-
KAE77_RS03530 (KAE77_03490)	743986..745914	+	1929	WP_011180275.1	phage terminase large subunit family protein	-
KAE77_RS03535 (KAE77_03495)	745918..746166	+	249	WP_011180274.1	hypothetical protein	-
KAE77_RS03540 (KAE77_03500)	746166..747722	+	1557	WP_011180273.1	phage portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	712997..784623	71626

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (15-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12135.97 Da
• Isoelectric Point: 9.0878

>T199121 WP_011180277.1 NZ_CP072899:c743349-743035 [Bartonella henselae]
MIHKRTNEGDLVIESFADKRCKDLLEGNPPKGFPTTLVRIVQRKLFMLDKAVDLKDLRSPPGNRLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Nucleotide

• Length: 315 bp

>T199121 NZ_CP097209:2869764-2871080 [Aeromonas caviae]
ATGATGGGTGGTTCTGAGCACCATCGGCTGGAACTTCGGCTGGGTAACCAGCTGATCGGCCATCTCGAATATGACTCCAG
CCGGGATGCGTTTCAGCTCGGCTATACACCTGAGTGGCAGGCGCGTGGCTTCCCGCTCTCCCCGCCGCTGGCGCTGGATG
GTTCGGCCAGCAGCGCCCAGATCCGGGCGTATCTCGGCAACTTGCTGCCTGAAAATCGCGGGCTGGAGCACCTGATTGAG
GCGCTCTCCGTTTCGCGCAGCAATCTCTTTGCCCTGATCCACGGCATCGGTCGCGATGTCTCAGGGGCGGTCACCTTTAC
CCTGCCCGCAGAGCCCGACGTCCCCACCCATTTTCGCCCCATCACCCCGAAAGAGCTGTTGCTGCGCCTCGATCAGCCCG
AGATCTGGCCGCTGGAAGTCTGGGATGGTCGCCCCCGCCTCTCGGTTGCGGGCGTGCAGGCCAAGCTCAACCTGCTGCGA
CTCGAGGGGACGCTGGGATTTGGCGAGGGCGAGCTCTGTTCCACCCACCTCCTCAAGTTCGAGCATCACCCTCATCTGGT
GATCAATGAGTTCGTGACCATGCGACTGGCCGCACTGCTGGGCATGCCGGTGGCGCGGGTCGAACTGCACAGGGTCGGCC
AAGGCGATAAGTCCCACCGAAGCTTGCTGGTGGAACGGTTCGATCGGCGCCTTGACGAGGATGGCTTGAGGGTGCGCCGT
CGTCACATGATCGATGCCTGTCAGGGGCTGGGGTTTCCCGTCGCCCGAAAATATGAACGCAACTTCGGTGACGGGCGGGA
CGTGGCCCATATTCGGGAAGGGGTGAGCCTGCCACGGCTGTTCAGTCTCAGCGCCCTCTGTGTCAATCCGGCGCAGGCCA
GACTGGACATGCTGCAATGGCTGCTCTTCAACCTCTGCGTCAACAACCACGATGCCCACGGCAAGAACTACAGCTTCTTC
GTATCAAAAGCAGGGCTGATGCCCACCCCCTGGTACGATCTGGTCAATGTGGGGCTTTACCCCGAGTTCAACCAGCATCT
GGCCATGGCCATAGGCGACGAGTTTGCTCCCGAGGCGGTCAACGCATGGCAGTTGCTGGAGATGGCCGAGGCATGCGAGC
TGCCCAAACGCCTGTTGCAGCAGACCTTGCACAAGATGGCCAGCGACATACTGCATCAGCTTGATGCCGCCATCGCCCTG
GTTGAGACAGACAATCCCGCCGAGCTGGCTTATCTGGCACGTTACAGAGACGACGTTGAGCACCGTTGCCACCATTTTCA
GGCGCAGGCGACGCTGTTGCCCGAGCTGCAACTGTAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11262.91 Da
• Isoelectric Point: 5.8690

>AT199121 WP_011180278.1 NZ_CP072899:c743018-742722 [Bartonella henselae]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSRITPDTALRLASFFDTTAEFWLNMQAAYDVSVL
QAEKADEFSKISKFECRV

Nucleotide

• Length: 297 bp

>AT199121 NZ_CP097209:2869484-2869780 [Aeromonas caviae]
ATGATGGCAGACGCATCGTTGCAAACCGGCCCGAAAGCACTGGATCCCGCCTCCCTGGGGCTGGCGATCCGCGAGAGACG
CAAGGCCGCCAGGATGACGCAGGAGGTGACGGCCTCACTGTGCGGTATCTCCAAGAAGACCCTGATCAAGATTGAAAAAG
GGGGGGATGTCTACCTCTCGACCCTGTTGCAGGTGATGAAGGCGCTGGGGCTGCGCTTGCAACTGGTGCAGGAAATGGGC
TCACAGGTAGCGAGCGGCAACAGCCAACCCGAGGTCGGTGATGATGGGTGGTTCTGA

Structures

Toxin

• AlphaFold DB: A0A0H3M2H0