Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1422633..1423067 Replicon chromosome
Accession NZ_CP072898
Organism Bartonella henselae strain FR96/BK38

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag KAE75_RS06180 Protein ID WP_236093265.1
Coordinates 1422633..1422758 (-) Length 42 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag KAE75_RS06185 Protein ID WP_236093266.1
Coordinates 1422894..1423067 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE75_RS06155 (KAE75_06145) 1418887..1420101 - 1215 WP_236093264.1 5-(carboxyamino)imidazole ribonucleotide synthase -
KAE75_RS06160 (KAE75_06150) 1420103..1420600 - 498 WP_011181203.1 5-(carboxyamino)imidazole ribonucleotide mutase -
KAE75_RS06165 (KAE75_06155) 1421260..1421406 + 147 WP_155245598.1 hypothetical protein -
KAE75_RS06170 1421843..1421926 + 84 WP_236087029.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAE75_RS06175 (KAE75_06165) 1421943..1422229 + 287 Protein_1211 HigA family addiction module antitoxin -
KAE75_RS06180 1422633..1422758 - 126 WP_236093265.1 type II toxin-antitoxin system YafQ family toxin Toxin
KAE75_RS06185 (KAE75_06175) 1422894..1423067 - 174 WP_236093266.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KAE75_RS06190 (KAE75_06180) 1423451..1423819 - 369 WP_051401505.1 hypothetical protein -
KAE75_RS06195 (KAE75_06185) 1424099..1424443 + 345 WP_034456524.1 hypothetical protein -
KAE75_RS06200 (KAE75_06190) 1424467..1424691 + 225 WP_143243623.1 hypothetical protein -
KAE75_RS06205 1424753..1424962 - 210 WP_034456520.1 hypothetical protein -
KAE75_RS06210 1425425..1425814 - 390 WP_034456517.1 hypothetical protein -
KAE75_RS06215 1425781..1425972 - 192 WP_172642315.1 HipA N-terminal domain-containing protein -
KAE75_RS06220 (KAE75_06200) 1426467..1426838 - 372 WP_034456515.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-41)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-54)


Sequences

Toxin        


Download         Length: 42 a.a.        Molecular weight: 4945.51 Da        Isoelectric Point: 6.1907

>T199109 WP_236093265.1 NZ_CP072898:c1422758-1422633 [Bartonella henselae]
MQGNWKPRCDLHREPDWLLIDSVNDEYVHCDRTGTHSNMFK

Download         Length: 126 bp

>T199109 NZ_CP097190:c2673933-2672611 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGATAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCACTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGTTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGCGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCTATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGACTGCAGGCGCTATAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6742.71 Da        Isoelectric Point: 5.0190

>AT199109 WP_236093266.1 NZ_CP072898:c1423067-1422894 [Bartonella henselae]
VSDFRGIAFTKVISEERLPFEMHIPNTETLKTFEKTDKGEDIFYAKDIKDFFKQLNI

Download         Length: 174 bp

>AT199109 NZ_CP097190:c2674199-2673933 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References