Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 694439..695066 Replicon chromosome
Accession NZ_CP072898
Organism Bartonella henselae strain FR96/BK38

Toxin (Protein)


Gene name higB Uniprot ID A0A0H3M2H0
Locus tag KAE75_RS03170 Protein ID WP_011180277.1
Coordinates 694752..695066 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag KAE75_RS03165 Protein ID WP_034454130.1
Coordinates 694439..694735 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE75_RS03125 (KAE75_03095) 689532..689852 + 321 WP_011180288.1 hypothetical protein -
KAE75_RS03130 (KAE75_03100) 689856..690434 + 579 WP_011180287.1 hypothetical protein -
KAE75_RS03135 (KAE75_03105) 691031..691573 + 543 WP_034454135.1 antA/AntB antirepressor family protein -
KAE75_RS03140 (KAE75_03110) 691605..692444 + 840 WP_011180284.1 antA/AntB antirepressor family protein -
KAE75_RS03145 (KAE75_03115) 692461..693180 + 720 WP_034454133.1 phage regulatory protein/antirepressor Ant -
KAE75_RS03150 (KAE75_03120) 693177..693455 + 279 WP_011180242.1 hypothetical protein -
KAE75_RS03155 (KAE75_03125) 693498..693779 - 282 WP_011180281.1 type II toxin-antitoxin system YafQ family toxin -
KAE75_RS03160 (KAE75_03130) 693766..694029 - 264 WP_011180280.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
KAE75_RS03165 (KAE75_03135) 694439..694735 - 297 WP_034454130.1 HigA family addiction module antitoxin Antitoxin
KAE75_RS03170 (KAE75_03140) 694752..695066 - 315 WP_011180277.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KAE75_RS03175 (KAE75_03145) 695129..695680 + 552 WP_034454327.1 hypothetical protein -
KAE75_RS03180 (KAE75_03150) 695711..697639 + 1929 WP_034454128.1 phage terminase large subunit family protein -
KAE75_RS03185 (KAE75_03155) 697643..697891 + 249 WP_011180274.1 hypothetical protein -
KAE75_RS03190 (KAE75_03160) 697891..699447 + 1557 WP_011180273.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 670210..737217 67007


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(15-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-80)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12135.97 Da        Isoelectric Point: 9.0878

>T199108 WP_011180277.1 NZ_CP072898:c695066-694752 [Bartonella henselae]
MIHKRTNEGDLVIESFADKRCKDLLEGNPPKGFPTTLVRIVQRKLFMLDKAVDLKDLRSPPGNRLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Download         Length: 315 bp

>T199108 NZ_CP097190:1957271-1957373 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11265.91 Da        Isoelectric Point: 5.1546

>AT199108 WP_034454130.1 NZ_CP072898:c694735-694439 [Bartonella henselae]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSPVTPDTALRLAYFFDTTAEFWLNMQAAYDVSVL
QAEKADEFSKISKFECRV

Download         Length: 297 bp

>AT199108 NZ_CP097190:c1957380-1957235 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3M2H0

Antitoxin

Source ID Structure

References