Detailed information of TA system TA199097

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 887382..887816
• Replicon: chromosome
• Accession: NZ_CP072897
• Organism: Bartonella henselae strain FR96/BK3

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: KAE70_RS03860
• Protein ID: WP_236095502.1
• Coordinates: 887691..887816 (+)
• Length: 42 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: KAE70_RS03855
• Protein ID: WP_236095501.1
• Coordinates: 887382..887555 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE70_RS03815 (KAE70_03650)	882499..882651	-	153	WP_011181195.1	DUF5993 family protein	-
KAE70_RS03820 (KAE70_03655)	883673..883963	+	291	WP_236095499.1	helix-turn-helix transcriptional regulator	-
KAE70_RS03825	884458..884649	+	192	WP_172642315.1	HipA N-terminal domain-containing protein	-
KAE70_RS03830	884616..885005	+	390	WP_034456517.1	hypothetical protein	-
KAE70_RS03835	885432..885677	+	246	WP_051524354.1	hypothetical protein	-
KAE70_RS03840 (KAE70_03665)	885756..885980	-	225	WP_143243623.1	hypothetical protein	-
KAE70_RS03845 (KAE70_03670)	886004..886348	-	345	WP_034454583.1	hypothetical protein	-
KAE70_RS03850 (KAE70_03675)	886628..886996	+	369	WP_236095500.1	hypothetical protein	-
KAE70_RS03855 (KAE70_03680)	887382..887555	+	174	WP_236095501.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KAE70_RS03860	887691..887816	+	126	WP_236095502.1	type II toxin-antitoxin system YafQ family toxin	Toxin
KAE70_RS03865 (KAE70_03690)	888279..888506	-	228	WP_011181202.1	HigA family addiction module antitoxin	-
KAE70_RS03870	888523..888606	-	84	WP_236087029.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KAE70_RS03875 (KAE70_03700)	889041..889187	-	147	WP_155245598.1	hypothetical protein	-
KAE70_RS03880 (KAE70_03705)	889914..890411	+	498	WP_011181203.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
KAE70_RS03885 (KAE70_03710)	890349..890900	-	552	WP_236095503.1	hypothetical protein	-
KAE70_RS03890 (KAE70_03715)	890809..891987	+	1179	WP_268885585.1	5-(carboxyamino)imidazole ribonucleotide synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-41)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-54)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4944.53 Da
• Isoelectric Point: 6.7020

>T199097 WP_236095502.1 NZ_CP072897:887691-887816 [Bartonella henselae]
MQGNWKPRCDLHREPNWLLIDSVNDEYVHCDRTGTHSNMFK

Nucleotide

• Length: 126 bp

>T199097 NZ_CP097181:3716524-3716802 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCATCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6732.67 Da
• Isoelectric Point: 5.0190

>AT199097 WP_236095501.1 NZ_CP072897:887382-887555 [Bartonella henselae]
VSDFRGIAFTKVISEERLPFEMHISNTETLKTFEKTDKGEDIFYAKDIKDFFKQLNI

Nucleotide

• Length: 174 bp

>AT199097 NZ_CP097181:3716261-3716521 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA