Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 717650..718343 Replicon chromosome
Accession NZ_CP072858
Organism Escherichia coli strain 184/2aE

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag J9158_RS03500 Protein ID WP_000415585.1
Coordinates 717650..717946 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag J9158_RS03505 Protein ID WP_000650107.1
Coordinates 717948..718343 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9158_RS23950 (712784) 712784..713263 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
J9158_RS23955 (713266) 713266..713976 + 711 WP_000834030.1 hypothetical protein -
J9158_RS03475 (713983) 713983..714315 + 333 WP_000914690.1 DUF2645 family protein -
J9158_RS03480 (714361) 714361..715710 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
J9158_RS03485 (715707) 715707..716366 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
J9158_RS03490 (716518) 716518..716910 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
J9158_RS03495 (716963) 716963..717445 + 483 WP_000183505.1 GyrI-like domain-containing protein -
J9158_RS03500 (717650) 717650..717946 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
J9158_RS03505 (717948) 717948..718343 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
J9158_RS03510 (718476) 718476..720083 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
J9158_RS03515 (720221) 720221..722479 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T199027 WP_000415585.1 NZ_CP072858:717650-717946 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T199027 NZ_CP097108:c2379692-2379378 [Pseudomonas bijieensis]
ATGATTTTTATTGAAACTCCAATTTTTACCCGTCGGGTCAAAGAACTGATGGATGACGATGATTTCGCTGTCCTACAGAA
AATACTGGTCTGCAATCCTTCCGCTGGTGATGTCATGGAAGCCACCGGAGGGATCCGAAAGATTCGTATCGCAGCCAAAG
GCCATGGCAAACGGGGTGGGGCCAGGGTGATCTACTACCACTTCGTCCATGCTTCGCGGATCGCATTACTGATGATATAT
CCGAAAAATGAACAGCAAGACTTGACCGTCGATCAACGCAAAGCATTGAAATTGATTGTCGAGCACTGGAGATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT199027 WP_000650107.1 NZ_CP072858:717948-718343 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT199027 NZ_CP097108:c2379375-2379088 [Pseudomonas bijieensis]
ATGAGCAAATTTTTCGATGAGCTGATGGAAAGCGTACAACAGATGGATGAAATCGTCCGAGGCGAACGCCAGCCGTCACG
GGAGTTCATCGTCGATGCGTTGCAAGTGAAGGAAATACGCAAGGCTACCGGCCTGACCCAAGCCAAGTTCGCAGCACTGA
TCGATGTCCAACTGGGCACGCTTCGCAACTGGGAGCAGGGACGACGCGAGCCTACCGGCCCCGCTAAAGCACTGCTGCGG
GCGATTCATAATGATCCGAAACACGTGATCAGCGCCCTAGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References