Detailed information of TA system TA198966

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe(toxin)
• Location: 1205359..1205870
• Replicon: chromosome
• Accession: NZ_CP072837
• Organism: Macrococcus canis strain 19/EPI0118

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: J9174_RS06185
• Protein ID: WP_210151720.1
• Coordinates: 1205610..1205870 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: J9174_RS06180
• Protein ID: WP_210151719.1
• Coordinates: 1205359..1205610 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9174_RS06155 (J9174_06155)	1200956..1201897	+	942	WP_188018993.1	LCP family protein	-
J9174_RS06160 (J9174_06160)	1201935..1202123	-	189	WP_086042483.1	2-hydroxymuconate tautomerase	-
J9174_RS06165 (J9174_06165)	1202172..1203176	-	1005	WP_210151716.1	cation diffusion facilitator family transporter	-
J9174_RS06170 (J9174_06170)	1203338..1203718	+	381	WP_210151717.1	sporulation protein	-
J9174_RS06175 (J9174_06175)	1203748..1204659	+	912	WP_210151718.1	hypothetical protein	-
J9174_RS06180 (J9174_06180)	1205359..1205610	+	252	WP_210151719.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J9174_RS06185 (J9174_06185)	1205610..1205870	+	261	WP_210151720.1	Txe/YoeB family addiction module toxin	Toxin
J9174_RS06190 (J9174_06190)	1205871..1206320	-	450	WP_210151721.1	GNAT family N-acetyltransferase	-
J9174_RS06195 (J9174_06195)	1206403..1207143	+	741	WP_210151722.1	hypothetical protein	-
J9174_RS06200 (J9174_06200)	1207153..1208043	+	891	WP_210151723.1	phosphotransferase	-
J9174_RS06205 (J9174_06205)	1208217..1208702	+	486	WP_210151724.1	NUDIX domain-containing protein	-
J9174_RS06210 (J9174_06210)	1208708..1209475	+	768	WP_210151725.1	hypothetical protein	-
J9174_RS06215 (J9174_06215)	1209493..1209765	-	273	WP_164953490.1	Txe/YoeB family addiction module toxin	-
J9174_RS06220 (J9174_06220)	1209758..1210015	-	258	WP_210151726.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
J9174_RS06225 (J9174_06225)	1210287..1210823	+	537	WP_210151727.1	GrpB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10245.91 Da
• Isoelectric Point: 10.1613

>T198966 WP_210151720.1 NZ_CP072837:1205610-1205870 [Macrococcus canis]
MYKIVLKSSVKKDLKKIKNTLLETNFLKIINQLKENPYNNNHSFEKLIPPIKGFYSRRINVQHRVVYTVNDEDKIVTIYS
AYGHYE

Nucleotide

• Length: 261 bp

>T198966 NZ_CP097076:c4589482-4589141 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTAACTGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAGCATTATGGCCTGACACTCAACGACACGCCGTTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCTGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGAGGATTC
AACTGGGAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9638.73 Da
• Isoelectric Point: 4.0948

>AT198966 WP_210151719.1 NZ_CP072837:1205359-1205610 [Macrococcus canis]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKYEEEIDFDSTW
DNI

Nucleotide

• Length: 252 bp

>AT198966 NZ_CP097076:c4589844-4589503 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCCAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCTGACCGGGCCAGTATCACCGGAAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA