Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1006642..1007197 Replicon chromosome
Accession NZ_CP072829
Organism Xiamenia xianingshaonis strain zg-886

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag J7S26_RS03735 Protein ID WP_261428733.1
Coordinates 1006642..1006929 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag J7S26_RS03740 Protein ID WP_261428734.1
Coordinates 1006913..1007197 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7S26_RS03715 (J7S26_03715) 1002291..1003622 + 1332 WP_166338649.1 radical SAM protein -
J7S26_RS03720 (J7S26_03720) 1003615..1004661 + 1047 WP_166338651.1 DUF169 domain-containing protein -
J7S26_RS03725 (J7S26_03725) 1004676..1005131 + 456 WP_166338653.1 GNAT family N-acetyltransferase -
J7S26_RS03730 (J7S26_03730) 1005219..1006451 + 1233 WP_166338655.1 (Fe-S)-binding protein -
J7S26_RS03735 1006642..1006929 + 288 WP_261428733.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J7S26_RS03740 1006913..1007197 + 285 WP_261428734.1 HigA family addiction module antitoxin Antitoxin
J7S26_RS03745 (J7S26_03740) 1007399..1008757 + 1359 WP_261428735.1 ABC transporter substrate-binding protein -
J7S26_RS03750 (J7S26_03745) 1008863..1009747 + 885 WP_166338659.1 ABC transporter permease subunit -
J7S26_RS03755 (J7S26_03750) 1009744..1010649 + 906 WP_166338661.1 ABC transporter permease subunit -
J7S26_RS03760 (J7S26_03755) 1010659..1011738 + 1080 WP_166338663.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 989698..1080078 90380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(10-82)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11275.89 Da        Isoelectric Point: 8.4837

>T198965 WP_261428733.1 NZ_CP072829:1006642-1006929 [Xiamenia xianingshaonis]
MYFKDRDIEAFWEDPGSFRSKKVPPEIRKLLFRKLQLLNAAHDLRDLRIPPANKLEKLKGDRAGQYSIRVNDQYRLCFVW
TEQGAEGVEFCDYHS

Download         Length: 288 bp

>T198965 NZ_CP097076:c4556760-4556227 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10338.94 Da        Isoelectric Point: 4.3000

>AT198965 WP_261428734.1 NZ_CP072829:1006913-1007197 [Xiamenia xianingshaonis]
VTTIHDFISTPGEILLEEFLEPLGISQYRLAQTIGKPQSAISDIVHGRRSISTEMACLLSAALGTSPEFWLNLQMTYDLK
TFDEAILASVPCLL

Download         Length: 285 bp

>AT198965 NZ_CP097076:c4557037-4556771 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCTAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References