Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 567157..567826 Replicon chromosome
Accession NZ_CP072829
Organism Xiamenia xianingshaonis strain zg-886

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag J7S26_RS01850 Protein ID WP_166338008.1
Coordinates 567157..567531 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J7S26_RS01855 Protein ID WP_165059525.1
Coordinates 567524..567826 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7S26_RS01830 (J7S26_01825) 562654..562965 + 312 WP_165059542.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
J7S26_RS01835 (J7S26_01830) 562965..564620 + 1656 WP_166338011.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
J7S26_RS01840 (J7S26_01835) 564772..566346 + 1575 WP_166338010.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
J7S26_RS01845 (J7S26_01840) 566699..566905 + 207 WP_166338009.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
J7S26_RS01850 (J7S26_01845) 567157..567531 + 375 WP_166338008.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J7S26_RS01855 (J7S26_01850) 567524..567826 + 303 WP_165059525.1 helix-turn-helix transcriptional regulator Antitoxin
J7S26_RS01860 (J7S26_01855) 568124..569647 + 1524 WP_166338007.1 alanine/glycine:cation symporter family protein -
J7S26_RS01865 (J7S26_01860) 569838..570368 + 531 WP_165059519.1 DUF308 domain-containing protein -
J7S26_RS01870 (J7S26_01865) 570469..572637 + 2169 WP_166338006.1 NAD-dependent DNA ligase LigA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-87)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14235.35 Da        Isoelectric Point: 9.3810

>T198964 WP_166338008.1 NZ_CP072829:567157-567531 [Xiamenia xianingshaonis]
MWSIEYEYIVDWLDKQDAETVAHVFAALELLERHGPSLGRPLVDTLADTKIRNLKELRPASSGSSEVRILFAFDPKRKAV
MLLAGDKAKGKNVRRKWSGWYKQAIPRAEEIYALHVRRLEETDG

Download         Length: 375 bp

>T198964 NZ_CP097076:3957467-3957685 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10955.43 Da        Isoelectric Point: 9.6552

>AT198964 WP_165059525.1 NZ_CP072829:567524-567826 [Xiamenia xianingshaonis]
MADLQEYLAKRGISSAQMDEARRDTQAKIDAYTLREARKASHMTQVQLAQAMGVSQNRVSRIESGDLDAMSVDSLRRYVN
ALGGSLTLVATLPTGQVRLT

Download         Length: 303 bp

>AT198964 NZ_CP097076:3957066-3957440 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References