Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1565235..1565788 Replicon chromosome
Accession NZ_CP072801
Organism Thiothrix litoralis strain AS

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J9253_RS07630 Protein ID WP_266097388.1
Coordinates 1565235..1565330 (+) Length 32 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J9253_RS07635 Protein ID WP_210224019.1
Coordinates 1565330..1565788 (+) Length 153 a.a.

Genomic Context

J9253_RS07625J9253_RS07630J9253_RS07635J9253_RS07640J9253_RS07645J9253_RS07650J9253_RS07655J9253_RS07585J9253_RS07590J9253_RS07595J9253_RS07600J9253_RS07605J9253_RS07610J9253_RS07615J9253_RS07620
Location: 1564930..1565106 (177 bp)
Type: Others
Protein ID: WP_210224018.1
Location: 1565235..1565330 (96 bp)
Type: Toxin
Protein ID: WP_266097388.1
Location: 1565330..1565788 (459 bp)
Type: Antitoxin
Protein ID: WP_210224019.1
Location: 1566026..1566661 (636 bp)
Type: Others
Protein ID: WP_210224020.1
Location: 1566861..1568144 (1284 bp)
Type: Others
Protein ID: WP_210224021.1
Location: 1568194..1568670 (477 bp)
Type: Others
Protein ID: WP_210224022.1
Location: 1568667..1569677 (1011 bp)
Type: Others
Protein ID: WP_210224023.1
Location: 1560491..1561024 (534 bp)
Type: Others
Protein ID: WP_210224011.1
Location: 1561043..1562302 (1260 bp)
Type: Others
Protein ID: WP_210224012.1
Location: 1562732..1562989 (258 bp)
Type: Others
Protein ID: WP_210224013.1
Location: 1563003..1563305 (303 bp)
Type: Others
Protein ID: WP_210224014.1
Location: 1563283..1563630 (348 bp)
Type: Others
Protein ID: WP_210224015.1
Location: 1563655..1564188 (534 bp)
Type: Others
Protein ID: WP_210224016.1
Location: 1564207..1564647 (441 bp)
Type: Others
Protein ID: WP_266097376.1
Location: 1564656..1564826 (171 bp)
Type: Others
Protein ID: WP_210224017.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J9253_RS07585 (J9253_07585)1560491..1561024-534WP_210224011.1ProQ/FINO family protein-
J9253_RS07590 (J9253_07590)1561043..1562302-1260WP_210224012.1tyrosine-type recombinase/integrase-
J9253_RS07595 (J9253_07595)1562732..1562989-258WP_210224013.1BrnA antitoxin family protein-
J9253_RS07600 (J9253_07600)1563003..1563305-303WP_210224014.1putative addiction module antidote protein-
J9253_RS07605 (J9253_07605)1563283..1563630-348WP_210224015.1type II toxin-antitoxin system RelE/ParE family toxin-
J9253_RS07610 (J9253_07610)1563655..1564188-534WP_210224016.1ProQ/FINO family protein-
J9253_RS07615 (J9253_07615)1564207..1564647-441WP_266097376.1hypothetical protein-
J9253_RS07620 (J9253_07620)1564656..1564826-171WP_210224017.1hypothetical protein-
J9253_RS07625 (J9253_07625)1564930..1565106+177WP_210224018.1DUF853 family protein-
J9253_RS07630 (J9253_07630)1565235..1565330+96WP_266097388.1type II toxin-antitoxin system HigB family toxinToxin
J9253_RS07635 (J9253_07635)1565330..1565788+459WP_210224019.1transcriptional regulatorAntitoxin
J9253_RS07640 (J9253_07640)1566026..1566661+636WP_210224020.1hypothetical protein-
J9253_RS07645 (J9253_07645)1566861..1568144+1284WP_210224021.1FAD-dependent oxidoreductase-
J9253_RS07650 (J9253_07650)1568194..1568670+477WP_210224022.1hypothetical protein-
J9253_RS07655 (J9253_07655)1568667..1569677+1011WP_210224023.1HlyD family secretion protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(1-21)

Antitoxin

Antitoxin HigA

(8-139)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3829.37 Da        Isoelectric Point: 8.0304

>T198886 WP_266097388.1 NZ_CP072801:1565235-1565330 [Thiothrix litoralis]
IEFRDNRMYVKHIVTHADYDKLCKKYAREAD

Download         Length: 96 bp

>T198886 NZ_CP097046:c2608396-2608253 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 153 a.a.        Molecular weight: 17257.60 Da        Isoelectric Point: 4.7387

>AT198886 WP_210224019.1 NZ_CP072801:1565330-1565788 [Thiothrix litoralis]
MDFAAVKTKAKELFAQASFISEIKHEADYENALALMEELLEDYDEHRTLIGILANAIEEWENVAPEFAEFNQRVAQLDDG
VAVLRTLIDQYQLKAEDLKNEIGSKSLVSMILNGSRNMTREHIQALSLRFNLNPAIFFHTTGLRLVSTSRKT

Download         Length: 459 bp

>AT198886 NZ_CP097046:2608134-2608320 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References