Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 662114..662883 Replicon chromosome
Accession NZ_CP072800
Organism Candidatus Thiothrix anitrata isolate A52

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J8380_RS03390 Protein ID WP_210228324.1
Coordinates 662114..662425 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J8380_RS03395 Protein ID WP_210228326.1
Coordinates 662425..662883 (+) Length 153 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8380_RS03370 (J8380_03370) 657196..658629 + 1434 WP_210228317.1 cell envelope integrity protein CreD -
J8380_RS03375 (J8380_03375) 658626..660194 + 1569 WP_210228318.1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase -
J8380_RS03380 (J8380_03380) 660245..660691 - 447 WP_210228319.1 hypothetical protein -
J8380_RS03385 (J8380_03385) 661127..661945 + 819 WP_210228320.1 metallophosphoesterase -
J8380_RS03390 (J8380_03390) 662114..662425 + 312 WP_210228324.1 type II toxin-antitoxin system HigB family toxin Toxin
J8380_RS03395 (J8380_03395) 662425..662883 + 459 WP_210228326.1 transcriptional regulator Antitoxin
J8380_RS03400 (J8380_03400) 662988..663986 + 999 WP_228292346.1 aspartate carbamoyltransferase catalytic subunit -
J8380_RS03405 (J8380_03405) 663983..665257 + 1275 WP_210228328.1 dihydroorotase -
J8380_RS03410 (J8380_03410) 665250..665714 + 465 WP_210228330.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
J8380_RS03415 (J8380_03415) 665724..666692 + 969 WP_210228331.1 bifunctional riboflavin kinase/FAD synthetase -
J8380_RS03420 (J8380_03420) 666689..667702 - 1014 WP_210228333.1 class 1 fructose-bisphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Antitoxin HigA

(8-140)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12096.87 Da        Isoelectric Point: 9.3653

>T198874 WP_210228324.1 NZ_CP072800:662114-662425 [Candidatus Thiothrix anitrata]
MHVISRKPFNDASLKFLNDADAIEAAYKTLRNDNFANPLALKAVFPSLDNFRYKDKWWVIDIGGNNLRLLAFIEFRDNRM
YVKHIVTHADYDKLCKKYAREAD

Download         Length: 312 bp

>T198874 NZ_CP097040:c37659-36796 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAGTTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGATCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAGCTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCAAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin


Download         Length: 153 a.a.        Molecular weight: 17156.49 Da        Isoelectric Point: 4.3389

>AT198874 WP_210228326.1 NZ_CP072800:662425-662883 [Candidatus Thiothrix anitrata]
MDFAAVKIQAKDLFTQAGFITEIRNDTDYENALALLEELLEDYDDYRTLIGILTNTIEAWENVAPEFAAFNQRIAQLDDG
VAVLRTLMDQYQLKADDLKNEIGGKSLVSMILNGSRNMTREHIQALSLRFNLNPSVFFRTASVPVTLHLVTT

Download         Length: 459 bp

>AT198874 NZ_CP097040:c37933-37661 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACTTTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGAATATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References