Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 333865..334471 Replicon chromosome
Accession NZ_CP072800
Organism Candidatus Thiothrix anitrata isolate A52

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J8380_RS01640 Protein ID WP_210227656.1
Coordinates 333865..334197 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J8380_RS01645 Protein ID WP_210227663.1
Coordinates 334184..334471 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8380_RS01620 (J8380_01620) 329558..330676 + 1119 WP_210227645.1 GNAT family N-acetyltransferase -
J8380_RS01625 (J8380_01625) 330797..331843 - 1047 WP_210227652.1 phage integrase N-terminal SAM-like domain-containing protein -
J8380_RS01630 (J8380_01630) 332085..332609 - 525 WP_210218106.1 hypothetical protein -
J8380_RS01635 (J8380_01635) 332610..333287 - 678 WP_210227654.1 hypothetical protein -
J8380_RS01640 (J8380_01640) 333865..334197 + 333 WP_210227656.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8380_RS01645 (J8380_01645) 334184..334471 + 288 WP_210227663.1 helix-turn-helix transcriptional regulator Antitoxin
J8380_RS01650 (J8380_01650) 334583..334837 + 255 WP_210227665.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J8380_RS01655 (J8380_01655) 334834..335262 + 429 WP_210227667.1 type II toxin-antitoxin system VapC family toxin -
J8380_RS01660 (J8380_01660) 335298..336452 - 1155 WP_210227669.1 deoxyguanosinetriphosphate triphosphohydrolase -
J8380_RS01665 (J8380_01665) 336449..337564 - 1116 WP_210227671.1 trypsin-like peptidase domain-containing protein -
J8380_RS01670 (J8380_01670) 337575..338495 - 921 WP_210227673.1 esterase-like activity of phytase family protein -
J8380_RS01675 (J8380_01675) 338683..338799 + 117 WP_210219385.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12545.54 Da        Isoelectric Point: 9.3928

>T198872 WP_210227656.1 NZ_CP072800:333865-334197 [Candidatus Thiothrix anitrata]
MDYTITYYSEDVQQQILELPDTLAARYVVLTRRMVALGPNLGEPHTKPFGGGLFELRLKGAEGIARVFYCTLVGRKIVML
HSFIKKSDKTPPRERETAEARMKEVKNENT

Download         Length: 333 bp

>T198872 NZ_CP097039:c62445-62104 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAATATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10675.32 Da        Isoelectric Point: 10.0889

>AT198872 WP_210227663.1 NZ_CP072800:334184-334471 [Candidatus Thiothrix anitrata]
MRTHDQLVDQLMSRPGVRAEVERIEQEETELLDQLLKTRLDAGLTQAQLAERMGTQASAIARLERSLATGKHSPSVATLR
RYIRACGKHLILRVA

Download         Length: 288 bp

>AT198872 NZ_CP097039:c62675-62445 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTAATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References