Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
| Location | 2026670..2027361 | Replicon | chromosome |
| Accession | NZ_CP072793 | ||
| Organism | Thiothrix unzii strain A1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | J9260_RS10135 | Protein ID | WP_210217670.1 |
| Coordinates | 2026670..2027020 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | J9260_RS10140 | Protein ID | WP_210217671.1 |
| Coordinates | 2027047..2027361 (+) | Length | 105 a.a. |
Genomic Context
Location: 2026670..2027020 (351 bp)
Type: Toxin
Protein ID: WP_210217670.1
Type: Toxin
Protein ID: WP_210217670.1
Location: 2027047..2027361 (315 bp)
Type: Antitoxin
Protein ID: WP_210217671.1
Type: Antitoxin
Protein ID: WP_210217671.1
Location: 2027445..2028533 (1089 bp)
Type: Others
Protein ID: WP_246499385.1
Type: Others
Protein ID: WP_246499385.1
Location: 2029637..2029831 (195 bp)
Type: Others
Protein ID: Protein_2000
Type: Others
Protein ID: Protein_2000
Location: 2029985..2032216 (2232 bp)
Type: Others
Protein ID: WP_210217673.1
Type: Others
Protein ID: WP_210217673.1
Location: 2021823..2022275 (453 bp)
Type: Others
Protein ID: WP_246499762.1
Type: Others
Protein ID: WP_246499762.1
Location: 2022286..2026482 (4197 bp)
Type: Others
Protein ID: WP_210217669.1
Type: Others
Protein ID: WP_210217669.1
Location: 2028536..2029594 (1059 bp)
Type: Others
Protein ID: WP_210217672.1
Type: Others
Protein ID: WP_210217672.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J9260_RS10125 (J9260_10120) | 2021823..2022275 | - | 453 | WP_246499762.1 | tRNA adenosine(34) deaminase TadA | - |
| J9260_RS10130 (J9260_10125) | 2022286..2026482 | - | 4197 | WP_210217669.1 | hypothetical protein | - |
| J9260_RS10135 (J9260_10130) | 2026670..2027020 | + | 351 | WP_210217670.1 | addiction module toxin RelE | Toxin |
| J9260_RS10140 (J9260_10135) | 2027047..2027361 | + | 315 | WP_210217671.1 | hypothetical protein | Antitoxin |
| J9260_RS10145 (J9260_10140) | 2027445..2028533 | + | 1089 | WP_246499385.1 | aminotransferase class V-fold PLP-dependent enzyme | - |
| J9260_RS10150 (J9260_10145) | 2028536..2029594 | - | 1059 | WP_210217672.1 | transposase | - |
| J9260_RS10155 (J9260_10150) | 2029637..2029831 | + | 195 | Protein_2000 | PLP-dependent transferase | - |
| J9260_RS10160 (J9260_10155) | 2029985..2032216 | + | 2232 | WP_210217673.1 | NADP-dependent isocitrate dehydrogenase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2028536..2029594 | 1058 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13653.57 Da Isoelectric Point: 9.1937
>T198867 WP_210217670.1 NZ_CP072793:2026670-2027020 [Thiothrix unzii]
MPQLPSFVELPSFERFREDYLNDDEYRDFQRLLIESPKAGDVIASTGGLRKIRFEDKRRGKGKRGGLRVIYYYQTNALEF
LLFAIYDKDEASDLTSKQKVAFKAFLESELKLRYPQ
MPQLPSFVELPSFERFREDYLNDDEYRDFQRLLIESPKAGDVIASTGGLRKIRFEDKRRGKGKRGGLRVIYYYQTNALEF
LLFAIYDKDEASDLTSKQKVAFKAFLESELKLRYPQ
Download Length: 351 bp
>T198867 NZ_CP097038:1801719-1802063 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTTGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAAGTGAAAGGATAATTTTCGTTAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTTCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGAAGGTCAGTTTAATTATTCTAATGTGGTTACCCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAAATAA
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTTGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAAGTGAAAGGATAATTTTCGTTAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTTCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGAAGGTCAGTTTAATTATTCTAATGTGGTTACCCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAAATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12083.06 Da Isoelectric Point: 10.3934
>AT198867 WP_210217671.1 NZ_CP072793:2027047-2027361 [Thiothrix unzii]
MKKRNLFDELMEGVEALKAEREGKITLKRVQLEVLESPAIQPSEILKLRESRHLSRSVFANAIRTNPRTVESWEQGRSKP
NPHAVLLMRLVEKYPETLEHLRAI
MKKRNLFDELMEGVEALKAEREGKITLKRVQLEVLESPAIQPSEILKLRESRHLSRSVFANAIRTNPRTVESWEQGRSKP
NPHAVLLMRLVEKYPETLEHLRAI
Download Length: 315 bp
>AT198867 NZ_CP097038:1801369-1801701 [Enterococcus faecalis]
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTTGACGGTGAGCCTTTGGATGATCATGATCGAGAAGTTATTCGTGCTTACTTAAAAGGAAG
ATTCGGAAAATAA
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTTGACGGTGAGCCTTTGGATGATCATGATCGAGAAGTTATTCGTGCTTACTTAAAAGGAAG
ATTCGGAAAATAA