Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2026670..2027361 Replicon chromosome
Accession NZ_CP072793
Organism Thiothrix unzii strain A1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J9260_RS10135 Protein ID WP_210217670.1
Coordinates 2026670..2027020 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J9260_RS10140 Protein ID WP_210217671.1
Coordinates 2027047..2027361 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9260_RS10125 (J9260_10120) 2021823..2022275 - 453 WP_246499762.1 tRNA adenosine(34) deaminase TadA -
J9260_RS10130 (J9260_10125) 2022286..2026482 - 4197 WP_210217669.1 hypothetical protein -
J9260_RS10135 (J9260_10130) 2026670..2027020 + 351 WP_210217670.1 addiction module toxin RelE Toxin
J9260_RS10140 (J9260_10135) 2027047..2027361 + 315 WP_210217671.1 hypothetical protein Antitoxin
J9260_RS10145 (J9260_10140) 2027445..2028533 + 1089 WP_246499385.1 aminotransferase class V-fold PLP-dependent enzyme -
J9260_RS10150 (J9260_10145) 2028536..2029594 - 1059 WP_210217672.1 transposase -
J9260_RS10155 (J9260_10150) 2029637..2029831 + 195 Protein_2000 PLP-dependent transferase -
J9260_RS10160 (J9260_10155) 2029985..2032216 + 2232 WP_210217673.1 NADP-dependent isocitrate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2028536..2029594 1058


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(45-101)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13653.57 Da        Isoelectric Point: 9.1937

>T198867 WP_210217670.1 NZ_CP072793:2026670-2027020 [Thiothrix unzii]
MPQLPSFVELPSFERFREDYLNDDEYRDFQRLLIESPKAGDVIASTGGLRKIRFEDKRRGKGKRGGLRVIYYYQTNALEF
LLFAIYDKDEASDLTSKQKVAFKAFLESELKLRYPQ

Download         Length: 351 bp

>T198867 NZ_CP097038:1801719-1802063 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTTGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAAGTGAAAGGATAATTTTCGTTAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTTCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATTCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCAGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGAAGGTCAGTTTAATTATTCTAATGTGGTTACCCATTACAATTTAAAGAT
GGGACAGGAAACTTATTTAAAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12083.06 Da        Isoelectric Point: 10.3934

>AT198867 WP_210217671.1 NZ_CP072793:2027047-2027361 [Thiothrix unzii]
MKKRNLFDELMEGVEALKAEREGKITLKRVQLEVLESPAIQPSEILKLRESRHLSRSVFANAIRTNPRTVESWEQGRSKP
NPHAVLLMRLVEKYPETLEHLRAI

Download         Length: 315 bp

>AT198867 NZ_CP097038:1801369-1801701 [Enterococcus faecalis]
ATGAACCTTTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTTGACGGTGAGCCTTTGGATGATCATGATCGAGAAGTTATTCGTGCTTACTTAAAAGGAAG
ATTCGGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References