Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1887352..1887985 Replicon chromosome
Accession NZ_CP072793
Organism Thiothrix unzii strain A1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J9260_RS09420 Protein ID WP_210217543.1
Coordinates 1887352..1887684 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J9260_RS09425 Protein ID WP_202717404.1
Coordinates 1887671..1887985 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9260_RS09400 (J9260_09395) 1885008..1885286 + 279 WP_210217539.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
J9260_RS09405 (J9260_09400) 1885283..1885720 + 438 WP_210217540.1 type II toxin-antitoxin system VapC family toxin -
J9260_RS09410 (J9260_09405) 1885820..1886788 - 969 WP_210217541.1 DUF1566 domain-containing protein -
J9260_RS09415 (J9260_09410) 1887094..1887315 + 222 WP_210217542.1 hypothetical protein -
J9260_RS09420 (J9260_09415) 1887352..1887684 + 333 WP_210217543.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9260_RS09425 (J9260_09420) 1887671..1887985 + 315 WP_202717404.1 hypothetical protein Antitoxin
J9260_RS09430 (J9260_09425) 1888099..1888644 - 546 WP_210217544.1 gamma carbonic anhydrase family protein -
J9260_RS09435 (J9260_09430) 1888646..1889218 - 573 WP_210217545.1 ribonuclease HII -
J9260_RS09440 (J9260_09435) 1889218..1889757 - 540 WP_210217546.1 hypothetical protein -
J9260_RS09445 (J9260_09440) 1889885..1890385 - 501 WP_210217547.1 class II aldolase/adducin family protein -
J9260_RS09450 (J9260_09445) 1890379..1891527 - 1149 WP_210217548.1 lipid-A-disaccharide synthase -
J9260_RS09455 (J9260_09450) 1891532..1892314 - 783 WP_210217549.1 acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase -
J9260_RS09460 (J9260_09455) 1892311..1892763 - 453 WP_210217550.1 3-hydroxyacyl-ACP dehydratase FabZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(8-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12848.57 Da        Isoelectric Point: 8.3571

>T198865 WP_210217543.1 NZ_CP072793:1887352-1887684 [Thiothrix unzii]
MKAVFVESTIFEKHRSAYLPDDEFQQFQSDLLENPLVGDVIQGTGGLRKVRVGIQGRGKRGGARVIYYYYDSFQRFYLLT
IYAKNEMSDLTADQKHQLKTFMEVWRNEQA

Download         Length: 333 bp

>T198865 NZ_CP097038:c300570-300475 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACAAGGAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11873.64 Da        Isoelectric Point: 10.4451

>AT198865 WP_202717404.1 NZ_CP072793:1887671-1887985 [Thiothrix unzii]
MSKRNLFEELSTALVEAKQHSEGKLTLRTHVVQRAGVPEIKPQEILTIREMFNMSRGVFARHLHTSARTLESWEQGRTAP
NGQAVTLLRLVQRHPETLSYIAEL

Download         Length: 315 bp

>AT198865 NZ_CP097038:300376-300440 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References