Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2197149..2198017 | Replicon | chromosome |
| Accession | NZ_CP072790 | ||
| Organism | Mycobacterium tuberculosis strain I0003447-5 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | J8397_RS10300 | Protein ID | WP_010886136.1 |
| Coordinates | 2197149..2197526 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | J8397_RS10305 | Protein ID | WP_003913306.1 |
| Coordinates | 2197568..2198017 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8397_RS10250 (J8397_10115) | 2192938..2193390 | - | 453 | WP_003899095.1 | lipoprotein | - |
| J8397_RS10255 (J8397_10120) | 2193454..2193855 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| J8397_RS10260 (J8397_10125) | 2193848..2194030 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| J8397_RS10265 (J8397_10130) | 2194144..2194494 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| J8397_RS10270 (J8397_10135) | 2194505..2195407 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| J8397_RS10275 (J8397_10140) | 2195428..2195619 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| J8397_RS10280 (J8397_10145) | 2195620..2195916 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| J8397_RS10285 (J8397_10150) | 2196156..2196371 | + | 216 | WP_003409878.1 | antitoxin | - |
| J8397_RS10290 (J8397_10155) | 2196368..2196679 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| J8397_RS10295 (J8397_10160) | 2196653..2197174 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| J8397_RS10300 (J8397_10165) | 2197149..2197526 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| J8397_RS10305 (J8397_10170) | 2197568..2198017 | + | 450 | WP_003913306.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| J8397_RS10310 (J8397_10175) | 2198014..2198559 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| J8397_RS10315 (J8397_10180) | 2198448..2199062 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| J8397_RS10320 (J8397_10185) | 2199111..2199407 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J8397_RS10325 (J8397_10190) | 2199404..2199655 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| J8397_RS10330 (J8397_10195) | 2199642..2200136 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| J8397_RS10335 (J8397_10200) | 2200296..2200703 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| J8397_RS10340 (J8397_10205) | 2200707..2200979 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| J8397_RS10345 (J8397_10210) | 2201012..2202232 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T198831 WP_010886136.1 NZ_CP072790:2197149-2197526 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T198831 NZ_CP097027:183503-183769 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATATTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGCGGAAATT
TATTCTGCCTGGACACATTATGAGTGA
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATATTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGCGGAAATT
TATTCTGCCTGGACACATTATGAGTGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16776.16 Da Isoelectric Point: 8.0771
>AT198831 WP_003913306.1 NZ_CP072790:2197568-2198017 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVS
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVS
Download Length: 450 bp
>AT198831 NZ_CP097027:183240-183503 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|