Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5526451..5527046 Replicon chromosome
Accession NZ_CP072783
Organism Pseudomonas aeruginosa strain LICME WGH-6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J9247_RS25830 Protein ID WP_079752024.1
Coordinates 5526768..5527046 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J9247_RS25825 Protein ID WP_033971055.1
Coordinates 5526451..5526756 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9247_RS25790 (J9247_25790) 5521744..5522016 - 273 WP_004352675.1 hypothetical protein -
J9247_RS25795 (J9247_25795) 5522126..5522392 + 267 WP_023088595.1 hypothetical protein -
J9247_RS25800 (J9247_25800) 5522448..5522783 + 336 WP_043086918.1 hypothetical protein -
J9247_RS25805 (J9247_25805) 5522845..5523522 - 678 WP_182375736.1 hypothetical protein -
J9247_RS25810 (J9247_25810) 5523519..5524403 - 885 WP_073652264.1 DNA-processing protein DprA -
J9247_RS25815 (J9247_25815) 5524508..5525464 - 957 WP_073652263.1 hypothetical protein -
J9247_RS25820 (J9247_25820) 5525712..5526125 - 414 WP_073652262.1 hypothetical protein -
J9247_RS25825 (J9247_25825) 5526451..5526756 - 306 WP_033971055.1 HigA family addiction module antitoxin Antitoxin
J9247_RS25830 (J9247_25830) 5526768..5527046 - 279 WP_079752024.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9247_RS25835 (J9247_25835) 5527099..5527494 - 396 Protein_5099 integrase -
J9247_RS25840 (J9247_25840) 5527564..5527983 - 420 WP_121358550.1 type II toxin-antitoxin system VapC family toxin -
J9247_RS25845 (J9247_25845) 5527980..5528225 - 246 WP_033971057.1 Arc family DNA-binding protein -
J9247_RS30920 5528251..5528523 - 273 Protein_5102 tyrosine-type recombinase/integrase -
J9247_RS25850 (J9247_25850) 5528883..5529086 + 204 WP_033971061.1 hypothetical protein -
J9247_RS25855 (J9247_25855) 5529268..5529420 - 153 WP_210224850.1 hypothetical protein -
J9247_RS25860 (J9247_25860) 5529508..5530023 - 516 WP_033971063.1 BRO family protein -
J9247_RS25865 (J9247_25865) 5530330..5530980 - 651 WP_033971066.1 carbonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5511431..5535475 24044


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10673.26 Da        Isoelectric Point: 8.5538

>T198700 WP_079752024.1 NZ_CP072783:c5527046-5526768 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAAKELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T198700 NZ_CP096957:c154540-154016 [Pseudomonas aeruginosa]
ATGAAAATCATCGGAGTGCAGGACCTCCCCTGCTACCGAATGCACACTCCCAAGTGGTCCGTTGCGCCTACATCTGGAGC
TGGAGCTGCAACTCAGGGTGGCCGGGTTAACCGAAAGGGGCTAGAGGCTCTATACCTCTCGCTTGAGTCGGCAACGGCCA
TTGCTGAGTTTCAGCAAGCAAGTGCATTCCTTCCACCTGGTCTGCTGGTCAGCTATTCCCTCAGTATGGATCGAGTGATC
GACTTCACCGGCGGCTATAACGATACCTGGGCCCCGATCTGGCAAGACTTTTTCTGCGACTGGAGAAAGATTCGCTTCAA
CGACGGCGTTGAACCGCCAAGCTGGATTATCGGGGATCTGGCTATCGAGGCTGACTGCGCTGGGATTCTGTTCGAGTCCG
TTGCGAACCCTGGAGGTCGGAACCTGGTGCTTTTCACCGATCAGTTGCCGGTGCATGGGAAACTTGTGGTCAACGATCCT
CGCGGGGATCTCCCTACCGACCAGTCATCTTGGACGCGCCCGTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11230.69 Da        Isoelectric Point: 4.4462

>AT198700 WP_033971055.1 NZ_CP072783:c5526756-5526451 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPTALARALNVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT198700 NZ_CP096957:c154932-154537 [Pseudomonas aeruginosa]
ATGGCCAGCAAAGCTGTATTAGAGCTTCGCCCCACCAACTTCGCGGGATTGATGGACGCTCTCAAAGAGGTGAACCGTGT
GATGTTCTCTCCTGAGCGCTTCCTCAAGGTTTTTTCGATGGACCAGCAGACCTTGGCGCTCCGGGCCCATGTCCATCGCA
ACACTGTGCGCAATGCGCCTGAATCGGAAAAGGTCCAGGCCTACATTCGTGATTCAGTGAAGGTTCTGCGCGCAGTGACC
GACATGGGCACGGACGTGACGAATGCCATCTTCTGGTTTAAGAACGAGCCTCTTTCCACGTTCGGCTATAAAACCGCGGA
GGAAGTGGTCAGCGAAGGAAAAACCGAGCAGCTGATCGCTTTCCTTCAATCCTGGGAAGCTGGTGCCCAAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References