198488

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2998097..2998745 Replicon chromosome
Accession NZ_CP072762
Organism Mycobacterium tuberculosis strain CG23

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag J8672_RS14120 Protein ID WP_003899414.1
Coordinates 2998097..2998420 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag J8672_RS14125 Protein ID WP_003899415.1
Coordinates 2998500..2998745 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8672_RS14095 (J8672_14095) 2993671..2994932 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
J8672_RS14100 (J8672_14100) 2994959..2995144 - 186 WP_009935348.1 hypothetical protein -
J8672_RS14105 (J8672_14105) 2995306..2996745 - 1440 WP_009935349.1 phage major capsid protein -
J8672_RS14110 (J8672_14110) 2996753..2997286 - 534 WP_003899412.1 HK97 family phage prohead protease -
J8672_RS14115 (J8672_14115) 2997439..2997930 - 492 WP_003900541.1 phage terminase small subunit P27 family -
J8672_RS14120 (J8672_14120) 2998097..2998420 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
J8672_RS14125 (J8672_14125) 2998500..2998745 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
J8672_RS14130 (J8672_14130) 2998742..3000169 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
J8672_RS14135 (J8672_14135) 3000171..3000563 - 393 WP_003899417.1 DUF2742 domain-containing protein -
J8672_RS14140 (J8672_14140) 3000560..3000820 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
J8672_RS14145 (J8672_14145) 3000837..3001199 - 363 WP_003900543.1 hypothetical protein -
J8672_RS14150 (J8672_14150) 3001202..3002329 - 1128 WP_003899420.1 site-specific integrase -
J8672_RS14155 (J8672_14155) 3002474..3002701 - 228 WP_003899421.1 hypothetical protein -
J8672_RS14160 (J8672_14160) 3002698..3003087 - 390 WP_003899422.1 hypothetical protein -
J8672_RS14165 (J8672_14165) 3002993..3003265 + 273 WP_003900544.1 hypothetical protein -
J8672_RS14170 (J8672_14170) 3003364..3003597 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2992062..3002329 10267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T198488 WP_003899414.1 NZ_CP072762:c2998420-2998097 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T198488 NZ_CP096848:719051-719446 [Mycobacterium tuberculosis variant bovis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT198488 WP_003899415.1 NZ_CP072762:c2998745-2998500 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT198488 NZ_CP096848:718797-719051 [Mycobacterium tuberculosis variant bovis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References