198427

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 3025033..3025681 Replicon chromosome
Accession NZ_CP072761
Organism Mycobacterium tuberculosis strain CG24

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag J8670_RS14240 Protein ID WP_003899414.1
Coordinates 3025033..3025356 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag J8670_RS14245 Protein ID WP_003899415.1
Coordinates 3025436..3025681 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8670_RS14220 (J8670_14220) 3020607..3021868 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
J8670_RS14225 (J8670_14225) 3022242..3023681 - 1440 WP_009935349.1 phage major capsid protein -
J8670_RS14230 (J8670_14230) 3023689..3024222 - 534 WP_003899412.1 HK97 family phage prohead protease -
J8670_RS14235 (J8670_14235) 3024375..3024866 - 492 WP_003900541.1 phage terminase small subunit P27 family -
J8670_RS14240 (J8670_14240) 3025033..3025356 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
J8670_RS14245 (J8670_14245) 3025436..3025681 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
J8670_RS14250 (J8670_14250) 3025678..3027105 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
J8670_RS14255 (J8670_14255) 3027107..3027499 - 393 WP_003899417.1 DUF2742 domain-containing protein -
J8670_RS14260 (J8670_14260) 3027496..3027756 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
J8670_RS14265 (J8670_14265) 3027773..3028135 - 363 WP_003900543.1 hypothetical protein -
J8670_RS14270 (J8670_14270) 3028138..3029265 - 1128 WP_003899420.1 site-specific integrase -
J8670_RS14275 (J8670_14275) 3029410..3029637 - 228 WP_003899421.1 hypothetical protein -
J8670_RS14280 (J8670_14280) 3029634..3030023 - 390 WP_003899422.1 hypothetical protein -
J8670_RS14285 (J8670_14285) 3029929..3030201 + 273 WP_003900544.1 hypothetical protein -
J8670_RS14290 (J8670_14290) 3030300..3030533 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 3018998..3029265 10267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T198427 WP_003899414.1 NZ_CP072761:c3025356-3025033 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T198427 NZ_CP096847:c697509-697117 [Mycobacterium tuberculosis variant bovis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT198427 WP_003899415.1 NZ_CP072761:c3025681-3025436 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT198427 NZ_CP096847:c697763-697506 [Mycobacterium tuberculosis variant bovis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References