Detailed information of TA system TA198361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1555782..1556428
• Replicon: chromosome
• Accession: NZ_CP072742
• Organism: Serratia fonticola strain R28

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: J8M99_RS07215
• Protein ID: WP_021807728.1
• Coordinates: 1556078..1556428 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A370SDA2
• Locus tag: J8M99_RS07210
• Protein ID: WP_021807729.1
• Coordinates: 1555782..1556081 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8M99_RS07195 (J8M99_07190)	1552316..1552513	+	198	WP_021807731.1	cellulose biosynthesis protein BcsF	-
J8M99_RS07200 (J8M99_07195)	1552516..1554171	+	1656	WP_115159797.1	cellulose biosynthesis protein BcsG	-
J8M99_RS07210 (J8M99_07205)	1555782..1556081	-	300	WP_021807729.1	helix-turn-helix transcriptional regulator	Antitoxin
J8M99_RS07215 (J8M99_07210)	1556078..1556428	-	351	WP_021807728.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J8M99_RS07220 (J8M99_07215)	1556655..1557644	-	990	WP_021807727.1	peptide ABC transporter ATP-binding protein	-
J8M99_RS07225 (J8M99_07220)	1557641..1558621	-	981	WP_021807726.1	dipeptide ABC transporter ATP-binding protein	-
J8M99_RS07230 (J8M99_07225)	1558636..1559538	-	903	WP_218520002.1	dipeptide ABC transporter permease DppC	-
J8M99_RS07235 (J8M99_07230)	1559550..1560569	-	1020	WP_071681699.1	dipeptide ABC transporter permease DppB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13591.49 Da
• Isoelectric Point: 5.2279

>T198361 WP_021807728.1 NZ_CP072742:c1556428-1556078 [Serratia fonticola]
MWTVIFTSTFDSWLQEQEEGMQEKVLADLMNLETYGPQLPRPYADTVKGSRYKNMKELRVQYSGRPIRAFFVFDPKRQAI
VLCAGDKSNDKRFYETMIRIADDEFTAYLATQEVSK

Nucleotide

• Length: 351 bp

>T198361 NZ_CP096845:3717321-3717578 [Mycobacterium tuberculosis variant bovis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10894.65 Da
• Isoelectric Point: 5.8719

>AT198361 WP_021807729.1 NZ_CP072742:c1556081-1555782 [Serratia fonticola]
MKTLRDAVAARSLESQARIKEMADEMMLETGLQLMRDELQLSQKSLAEAMGVSQSAVAQIEQRGNDVKLATLKRYIEAMG
GKLSLTVEMPEGGGRVFHI

Nucleotide

• Length: 300 bp

>AT198361 NZ_CP096845:3717049-3717324 [Mycobacterium tuberculosis variant bovis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A370SDA2