Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2775191..2775693 | Replicon | chromosome |
| Accession | NZ_CP072689 | ||
| Organism | Escherichia marmotae strain YF8 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | J8I93_RS13280 | Protein ID | WP_000767829.1 |
| Coordinates | 2775191..2775445 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | J8I93_RS13285 | Protein ID | WP_001259255.1 |
| Coordinates | 2775442..2775693 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8I93_RS13250 (2770206) | 2770206..2770433 | - | 228 | WP_000985267.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| J8I93_RS13255 (2770447) | 2770447..2771505 | - | 1059 | WP_000492321.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| J8I93_RS13260 (2771684) | 2771684..2773042 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| J8I93_RS13265 (2773032) | 2773032..2773094 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| J8I93_RS13270 (2773309) | 2773309..2774238 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| J8I93_RS13275 (2774284) | 2774284..2775108 | - | 825 | WP_000754734.1 | SDR family oxidoreductase | - |
| J8I93_RS13280 (2775191) | 2775191..2775445 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| J8I93_RS13285 (2775442) | 2775442..2775693 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| J8I93_RS13290 (2775976) | 2775976..2776026 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| J8I93_RS13295 (2776172) | 2776172..2777071 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| J8I93_RS13300 (2777077) | 2777077..2778381 | + | 1305 | WP_001468360.1 | histidinol dehydrogenase | - |
| J8I93_RS13305 (2778378) | 2778378..2779448 | + | 1071 | WP_001099222.1 | histidinol-phosphate transaminase | - |
| J8I93_RS13310 (2779448) | 2779448..2780515 | + | 1068 | WP_000080068.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T198330 WP_000767829.1 NZ_CP072689:c2775445-2775191 [Escherichia marmotae]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T198330 NZ_CP096845:c1386989-1386696 [Mycobacterium tuberculosis variant bovis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT198330 WP_001259255.1 NZ_CP072689:c2775693-2775442 [Escherichia marmotae]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT198330 NZ_CP096845:c1387255-1386986 [Mycobacterium tuberculosis variant bovis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|