Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2247774..2248336 Replicon chromosome
Accession NZ_CP072689
Organism Escherichia marmotae strain YF8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J8I93_RS10540 Protein ID WP_192856131.1
Coordinates 2247774..2248052 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag J8I93_RS10545 Protein ID WP_000781370.1
Coordinates 2248052..2248336 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I93_RS10515 (2243394) 2243394..2243825 - 432 WP_000152293.1 peroxiredoxin OsmC -
J8I93_RS10520 (2244148) 2244148..2244363 + 216 WP_000495761.1 biofilm-dependent modulation protein -
J8I93_RS10525 (2244454) 2244454..2244591 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
J8I93_RS10530 (2244747) 2244747..2246444 + 1698 WP_001516384.1 malate dehydrogenase -
J8I93_RS10535 (2246578) 2246578..2247588 + 1011 WP_061090620.1 alcohol dehydrogenase AdhP -
J8I93_RS10540 (2247774) 2247774..2248052 + 279 WP_192856131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8I93_RS10545 (2248052) 2248052..2248336 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
J8I93_RS10550 (2248564) 2248564..2249217 - 654 WP_000045637.1 formate dehydrogenase-N subunit gamma -
J8I93_RS10555 (2249210) 2249210..2250094 - 885 WP_001240589.1 formate dehydrogenase N subunit beta -
J8I93_RS10560 (2250107) 2250107..2253154 - 3048 WP_077633351.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10695.26 Da        Isoelectric Point: 6.4760

>T198323 WP_192856131.1 NZ_CP072689:2247774-2248052 [Escherichia marmotae]
MIMNFRHKELRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDEIWTISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T198323 NZ_CP096845:c754041-753604 [Mycobacterium tuberculosis variant bovis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT198323 WP_000781370.1 NZ_CP072689:2248052-2248336 [Escherichia marmotae]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT198323 NZ_CP096845:c754292-754038 [Mycobacterium tuberculosis variant bovis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References