Detailed information of TA system TA198298

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2259361..2259732
• Replicon: chromosome
• Accession: NZ_CP072688
• Organism: Escherichia coli strain P4

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: -
• Locus tag: J8I92_RS10790
• Protein ID: WP_042047457.1
• Coordinates: 2259538..2259732 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2259361..2259539 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8I92_RS10750 (2254805)	2254805..2255461	-	657	WP_000011664.1	carbon-nitrogen hydrolase family protein YobB	-
J8I92_RS10755 (2255563)	2255563..2255793	-	231	WP_000916763.1	DNA polymerase III subunit theta	-
J8I92_RS10760 (2255932)	2255932..2256306	+	375	WP_000168747.1	CopC domain-containing protein YobA	-
J8I92_RS10765 (2256310)	2256310..2257182	+	873	WP_000879311.1	copper homeostasis membrane protein CopD	-
J8I92_RS10770 (2257195)	2257195..2257536	+	342	WP_000977376.1	YebY family protein	-
J8I92_RS10775 (2257927)	2257927..2259003	-	1077	WP_001189088.1	phage integrase Arm DNA-binding domain-containing protein	-
J8I92_RS10780 (2258969)	2258969..2259250	-	282	WP_023234152.1	excisionase	-
- (2259361)	2259361..2259539	+	179	NuclAT_0	-	Antitoxin
- (2259361)	2259361..2259539	+	179	NuclAT_0	-	Antitoxin
- (2259361)	2259361..2259539	+	179	NuclAT_0	-	Antitoxin
- (2259361)	2259361..2259539	+	179	NuclAT_0	-	Antitoxin
J8I92_RS10785 (2259357)	2259357..2259545	-	189	WP_001356607.1	DUF1187 family protein	-
J8I92_RS10790 (2259538)	2259538..2259732	-	195	WP_042047457.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
J8I92_RS10795 (2259789)	2259789..2260598	-	810	WP_000166317.1	recombination protein RecT	-
J8I92_RS10800 (2260591)	2260591..2263266	-	2676	WP_000102215.1	exodeoxyribonuclease VIII	-
J8I92_RS10805 (2263367)	2263367..2263642	-	276	WP_001519830.1	phage protein	-
J8I92_RS10810 (2263717)	2263717..2263887	-	171	WP_001359121.1	YdaE family protein	-
J8I92_RS10815 (2263887)	2263887..2264108	-	222	WP_000560227.1	cell division protein FtsZ	-
J8I92_RS10820 (2264520)	2264520..2264672	-	153	WP_000379544.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2250155..2314625	64470

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 6959.83 Da
• Isoelectric Point: 8.5005

>T198298 WP_042047457.1 NZ_CP072688:c2259732-2259538 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKAISGYCRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T198298 NZ_CP096844:c3038180-3037785 [Mycobacterium tuberculosis variant bovis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT198298 NZ_CP072688:2259361-2259539 [Escherichia coli]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Structures

Antitoxin