Detailed information of TA system TA198281

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4221562..4221971
• Replicon: chromosome
• Accession: NZ_CP072687
• Organism: Escherichia coli strain YP3

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: J8I95_RS20360
• Protein ID: WP_001534835.1
• Coordinates: 4221633..4221971 (+)
• Length: 113 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4221562..4221638 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8I95_RS20350 (4216750)	4216750..4218060	+	1311	WP_001534837.1	restriction endonuclease subunit S	-
J8I95_RS20355 (4218155)	4218155..4221418	+	3264	WP_001534836.1	HsdR family type I site-specific deoxyribonuclease	-
- (4221562)	4221562..4221638	-	77	NuclAT_12	-	Antitoxin
- (4221562)	4221562..4221638	-	77	NuclAT_12	-	Antitoxin
- (4221562)	4221562..4221638	-	77	NuclAT_12	-	Antitoxin
- (4221562)	4221562..4221638	-	77	NuclAT_12	-	Antitoxin
- (4221562)	4221562..4221638	-	77	NuclAT_13	-	Antitoxin
- (4221562)	4221562..4221638	-	77	NuclAT_13	-	Antitoxin
- (4221562)	4221562..4221638	-	77	NuclAT_13	-	Antitoxin
- (4221562)	4221562..4221638	-	77	NuclAT_13	-	Antitoxin
J8I95_RS20360 (4221633)	4221633..4221971	+	339	WP_001534835.1	endoribonuclease SymE	Toxin
J8I95_RS20365 (4222059)	4222059..4222193	-	135	WP_001314403.1	hypothetical protein	-
J8I95_RS20370 (4222355)	4222355..4222663	+	309	Protein_3993	winged helix-turn-helix domain-containing protein	-
J8I95_RS20375 (4222655)	4222655..4223575	-	921	WP_000181193.1	Rpn family recombination-promoting nuclease/putative transposase	-
J8I95_RS20380 (4223760)	4223760..4225040	+	1281	WP_001535800.1	DUF445 domain-containing protein	-
J8I95_RS20385 (4225156)	4225156..4226307	+	1152	WP_001338076.1	double-cubane-cluster-containing anaerobic reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12310.04 Da
• Isoelectric Point: 7.8226

>T198281 WP_001534835.1 NZ_CP072687:4221633-4221971 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYNRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQDFIGVISNKTPR

Nucleotide

• Length: 339 bp

>T198281 NZ_CP096844:c2196988-2196659 [Mycobacterium tuberculosis variant bovis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT198281 NZ_CP072687:c4221638-4221562 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin