Detailed information of TA system TA198279

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4143547..4143805
• Replicon: chromosome
• Accession: NZ_CP072687
• Organism: Escherichia coli strain YP3

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: J8I95_RS19970
• Protein ID: WP_000809168.1
• Coordinates: 4143653..4143805 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4143547..4143604 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8I95_RS19955	4139376..4140635	-	1260	WP_000494928.1	hypothetical protein	-
J8I95_RS19960	4140764..4142257	-	1494	WP_001468392.1	sulfatase-like hydrolase/transferase	-
J8I95_RS19965	4142277..4143038	-	762	WP_001274832.1	outer membrane protein OmpK	-
-	4143547..4143604	-	58	-	-	Antitoxin
J8I95_RS19970	4143653..4143805	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
J8I95_RS19975	4143910..4145040	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
J8I95_RS19980	4145129..4147045	-	1917	WP_000516135.1	molecular chaperone DnaK	-
J8I95_RS19985	4147418..4147822	+	405	WP_000843687.1	DUF2541 family protein	-
J8I95_RS19990	4147848..4148561	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T198279 WP_000809168.1 NZ_CP072687:4143653-4143805 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T198279 NZ_CP096844:c1940657-1940268 [Mycobacterium tuberculosis variant bovis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT198279 NZ_CP072687:c4143604-4143547 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin