Detailed information of TA system TA198259

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 239389..239611
• Replicon: chromosome
• Accession: NZ_CP072687
• Organism: Escherichia coli strain YP3

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A0D6GD35
• Locus tag: J8I95_RS01190
• Protein ID: WP_000170745.1
• Coordinates: 239504..239611 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	239389..239447 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8I95_RS01170	234830..235732	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
J8I95_RS01175	235743..236726	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
J8I95_RS01180	236723..237727	+	1005	WP_000103583.1	dipeptide ABC transporter ATP-binding subunit DppF	-
J8I95_RS01185	237757..239028	-	1272	WP_001467807.1	amino acid permease	-
-	239389..239447	-	59	-	-	Antitoxin
J8I95_RS01190	239504..239611	+	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
J8I95_RS01195	239698..241377	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
J8I95_RS01200	241374..241565	-	192	WP_000988311.1	cellulose biosynthesis protein BcsF	-
J8I95_RS01205	241562..243133	-	1572	WP_001204945.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
J8I95_RS01210	243406..243594	+	189	WP_001063314.1	cellulose biosynthesis protein BcsR	-
J8I95_RS01215	243606..244358	+	753	WP_000279525.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3855.68 Da
• Isoelectric Point: 9.0157

>T198259 WP_000170745.1 NZ_CP072687:239504-239611 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVSWLNKRK

Nucleotide

• Length: 108 bp

>T198259 NZ_CP096844:c698449-698036 [Mycobacterium tuberculosis variant bovis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT198259 NZ_CP072687:c239447-239389 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0D6GD35

Antitoxin