Detailed information of TA system TA198248

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2259110..2259481
• Replicon: chromosome
• Accession: NZ_CP072686
• Organism: Escherichia coli strain FP4

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: -
• Locus tag: J8I94_RS10780
• Protein ID: WP_042047457.1
• Coordinates: 2259287..2259481 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2259110..2259288 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8I94_RS10740 (2254554)	2254554..2255210	-	657	WP_000011664.1	carbon-nitrogen hydrolase family protein YobB	-
J8I94_RS10745 (2255312)	2255312..2255542	-	231	WP_000916763.1	DNA polymerase III subunit theta	-
J8I94_RS10750 (2255681)	2255681..2256055	+	375	WP_000168747.1	CopC domain-containing protein YobA	-
J8I94_RS10755 (2256059)	2256059..2256931	+	873	WP_000879311.1	copper homeostasis membrane protein CopD	-
J8I94_RS10760 (2256944)	2256944..2257285	+	342	WP_000977376.1	YebY family protein	-
J8I94_RS10765 (2257676)	2257676..2258752	-	1077	WP_001189088.1	phage integrase Arm DNA-binding domain-containing protein	-
J8I94_RS10770 (2258718)	2258718..2258999	-	282	WP_023234152.1	excisionase	-
- (2259110)	2259110..2259288	+	179	NuclAT_0	-	Antitoxin
- (2259110)	2259110..2259288	+	179	NuclAT_0	-	Antitoxin
- (2259110)	2259110..2259288	+	179	NuclAT_0	-	Antitoxin
- (2259110)	2259110..2259288	+	179	NuclAT_0	-	Antitoxin
J8I94_RS10775 (2259106)	2259106..2259294	-	189	WP_001356607.1	DUF1187 family protein	-
J8I94_RS10780 (2259287)	2259287..2259481	-	195	WP_042047457.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
J8I94_RS10785 (2259538)	2259538..2260345	-	808	Protein_2112	recombination protein RecT	-
J8I94_RS10790 (2260338)	2260338..2263013	-	2676	WP_000102215.1	exodeoxyribonuclease VIII	-
J8I94_RS10795 (2263114)	2263114..2263389	-	276	WP_001519830.1	phage protein	-
J8I94_RS10800 (2263464)	2263464..2263634	-	171	WP_001359121.1	YdaE family protein	-
J8I94_RS10805 (2263634)	2263634..2263855	-	222	WP_000560227.1	cell division protein FtsZ	-
J8I94_RS10810 (2264267)	2264267..2264419	-	153	WP_000379544.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2251812..2314372	62560

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 6959.83 Da
• Isoelectric Point: 8.5005

>T198248 WP_042047457.1 NZ_CP072686:c2259481-2259287 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKAISGYCRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T198248 NZ_CP096843:c3656696-3656268 [Mycobacterium tuberculosis variant bovis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Nucleotide

• Length: 179 bp

>AT198248 NZ_CP072686:2259110-2259288 [Escherichia coli]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Structures

Antitoxin