Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2341110..2341618 Replicon chromosome
Accession NZ_CP072652
Organism Serratia symbiotica strain 24.1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7X3T0F2
Locus tag GPZ83_RS12105 Protein ID WP_071985748.1
Coordinates 2341110..2341376 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E9CKE8
Locus tag GPZ83_RS12110 Protein ID WP_006708173.1
Coordinates 2341373..2341618 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPZ83_RS12080 (GPZ83_0012075) 2336439..2337860 - 1422 WP_040262827.1 sulfate adenylyltransferase subunit CysN -
GPZ83_RS12085 (GPZ83_0012080) 2337872..2338780 - 909 WP_040262899.1 sulfate adenylyltransferase subunit CysD -
GPZ83_RS12090 (GPZ83_0012085) 2338803..2340233 - 1431 WP_040262825.1 siroheme synthase CysG -
GPZ83_RS12095 (GPZ83_0012090) 2340286..2340588 - 303 WP_180192823.1 hypothetical protein -
GPZ83_RS12100 (GPZ83_0012095) 2340548..2341006 - 459 WP_180192822.1 hypothetical protein -
GPZ83_RS12105 (GPZ83_0012100) 2341110..2341376 - 267 WP_071985748.1 Txe/YoeB family addiction module toxin Toxin
GPZ83_RS12110 (GPZ83_0012105) 2341373..2341618 - 246 WP_006708173.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPZ83_RS12115 (GPZ83_0012110) 2341685..2341852 - 168 WP_160744652.1 hypothetical protein -
GPZ83_RS12120 (GPZ83_0012115) 2341880..2342125 - 246 WP_052447611.1 hypothetical protein -
GPZ83_RS15885 2342403..2342567 - 165 Protein_2221 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
GPZ83_RS12125 (GPZ83_0012120) 2342639..2343807 + 1169 WP_180192787.1 IS3 family transposase -
GPZ83_RS12130 (GPZ83_0012125) 2343800..2344954 - 1155 WP_226020287.1 tyrosine-type recombinase/integrase -
GPZ83_RS12135 (GPZ83_0012130) 2345208..2345444 + 237 WP_209520065.1 hypothetical protein -
GPZ83_RS12140 (GPZ83_0012135) 2345754..2346482 - 729 WP_040262810.1 phosphoadenylyl-sulfate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2340286..2357757 17471


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10572.24 Da        Isoelectric Point: 10.5562

>T198202 WP_071985748.1 NZ_CP072652:c2341376-2341110 [Serratia symbiotica]
MKIRFTRRAATDFQYWQKNNVKVYERVRLLIKAAHADPFCGIGKPERLRHHKNPALYSRRIDREHRLVYSVTDGELTIIA
CRFHYESL

Download         Length: 267 bp

>T198202 NZ_CP096843:c698627-698214 [Mycobacterium tuberculosis variant bovis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9123.26 Da        Isoelectric Point: 4.6069

>AT198202 WP_006708173.1 NZ_CP072652:c2341618-2341373 [Serratia symbiotica]
MHALTFTDARKHFAETMQRVSDNAEPVRILRRDAPDVIIIGAHEYDAMVETLHLFSNPVNAAHINASLDELERGDIVEID
V

Download         Length: 246 bp

>AT198202 NZ_CP096843:c698860-698624 [Mycobacterium tuberculosis variant bovis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X3T0F2

Antitoxin

Source ID Structure
AlphaFold DB A0A068YWA6

References