Detailed information of TA system TA198198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 842222..842973
• Replicon: chromosome
• Accession: NZ_CP072652
• Organism: Serratia symbiotica strain 24.1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GPZ83_RS05020
• Protein ID: WP_040265116.1
• Coordinates: 842662..842973 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GPZ83_RS05015
• Protein ID: WP_160744087.1
• Coordinates: 842222..842665 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPZ83_RS04980 (GPZ83_0004975)	837436..838113	+	678	WP_244986325.1	thioesterase domain-containing protein	-
GPZ83_RS04985 (GPZ83_0004980)	838195..839451	+	1257	WP_160744089.1	enterobactin transporter EntS	-
GPZ83_RS04990 (GPZ83_0004985)	839452..839667	-	216	WP_040264958.1	hypothetical protein	-
GPZ83_RS04995 (GPZ83_0004990)	839667..839990	-	324	WP_152609097.1	hypothetical protein	-
GPZ83_RS05000 (GPZ83_0004995)	840146..841061	-	916	Protein_825	ABC transporter transmembrane domain-containing protein	-
GPZ83_RS05005 (GPZ83_0005000)	841082..842031	-	950	Protein_826	HlyD family efflux transporter periplasmic adaptor subunit	-
GPZ83_RS05015 (GPZ83_0005010)	842222..842665	-	444	WP_160744087.1	helix-turn-helix domain-containing protein	Antitoxin
GPZ83_RS05020 (GPZ83_0005015)	842662..842973	-	312	WP_040265116.1	type II toxin-antitoxin system HigB family toxin	Toxin
GPZ83_RS15635	843093..843203	-	111	Protein_829	hypothetical protein	-
GPZ83_RS05025 (GPZ83_0005020)	843308..843814	-	507	Protein_830	helix-turn-helix domain-containing protein	-
GPZ83_RS05030 (GPZ83_0005025)	843967..844494	-	528	Protein_831	integrase core domain-containing protein	-
GPZ83_RS05035 (GPZ83_0005030)	844502..845065	-	564	WP_160744086.1	DedA family protein	-
GPZ83_RS05040 (GPZ83_0005035)	845463..846377	+	915	WP_040264962.1	D-alanyl-D-alanine endopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	803224..848172	44948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (22-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (92-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12338.38 Da
• Isoelectric Point: 10.3183

>T198198 WP_040265116.1 NZ_CP072652:c842973-842662 [Serratia symbiotica]
VHVISRQPFNEAAGKYPNSALALLYLMRVLEKKTFNSPDEMKRAIPSLNNFKYRKKWWVIDVFGNTVRLMAFIDFEKQKV
FVKHIATHAEYDKLTKYYREHKE

Nucleotide

• Length: 312 bp

>T198198 NZ_CP096843:365001-365426 [Mycobacterium tuberculosis variant bovis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16060.34 Da
• Isoelectric Point: 4.8056

>AT198198 WP_160744087.1 NZ_CP072652:c842665-842222 [Serratia symbiotica]
MTVATHIDTASAESMIATFANAVKCIPLMTGDKSEAEYNKALELIEYLVDRDELSNPLFEPLAAKITEYENSAPEFEAFN
RRLAEIPTGVAALHTLMDQHGLKAADLIDELGSKSNVSNILSGRRALTVKHIKALASRFNVPADLFI

Nucleotide

• Length: 444 bp

>AT198198 NZ_CP096843:364783-365004 [Mycobacterium tuberculosis variant bovis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA