Detailed information of TA system TA198164

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2314918..2315618
• Replicon: chromosome
• Accession: NZ_CP072610
• Organism: Pseudomonas wenzhouensis strain A20

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: J7655_RS10610
• Protein ID: WP_147811842.1
• Coordinates: 2314918..2315214 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A1H2LFQ3
• Locus tag: J7655_RS10615
• Protein ID: WP_031306592.1
• Coordinates: 2315217..2315618 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J7655_RS10575 (J7655_10530)	2310536..2310850	-	315	WP_012018520.1	hypothetical protein	-
J7655_RS10580 (J7655_10535)	2311014..2311397	+	384	WP_230924410.1	hypothetical protein	-
J7655_RS10585 (J7655_10540)	2311517..2312206	-	690	WP_075747856.1	crotonase/enoyl-CoA hydratase family protein	-
J7655_RS10590 (J7655_10545)	2312394..2312612	+	219	WP_230924411.1	hypothetical protein	-
J7655_RS10600 (J7655_10555)	2312899..2313699	+	801	WP_230924412.1	hypothetical protein	-
J7655_RS10605 (J7655_10560)	2313971..2314741	+	771	WP_230924413.1	hypothetical protein	-
J7655_RS10610 (J7655_10565)	2314918..2315214	+	297	WP_147811842.1	type II toxin-antitoxin system MqsR family toxin	Toxin
J7655_RS10615 (J7655_10570)	2315217..2315618	+	402	WP_031306592.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
J7655_RS10620 (J7655_10575)	2316153..2317325	+	1173	WP_230924414.1	elongation factor P maturation arginine rhamnosyltransferase EarP	-
J7655_RS10625 (J7655_10580)	2317360..2317932	+	573	WP_074678540.1	elongation factor P	-
J7655_RS10630 (J7655_10585)	2318040..2319464	+	1425	WP_230924415.1	IS1182 family transposase	-
J7655_RS10635 (J7655_10590)	2319611..2320573	-	963	WP_230924416.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2318040..2319464	1424

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11328.11 Da
• Isoelectric Point: 8.4579

>T198164 WP_147811842.1 NZ_CP072610:2314918-2315214 [Pseudomonas wenzhouensis]
MEKRKPHFRLELVKQAVADQRYRFTRVALEGGAALGMEMADMLAVISALSSRDFFKSMTTYADHTTWQDVYRPDTEFGQV
YLKFTLVADLLIVSFKEK

Nucleotide

• Length: 297 bp

>T198164 NZ_CP096842:1687444-1687761 [Mycobacterium tuberculosis variant bovis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14781.69 Da
• Isoelectric Point: 6.4554

>AT198164 WP_031306592.1 NZ_CP072610:2315217-2315618 [Pseudomonas wenzhouensis]
MKCPVCGGAELVHDTRDMPFTYKGQTTQITAVTADWCDACGESLTGPAESERVMRAMNEFRQQVNAQDGNQELIRSVRKQ
LRLSQREAAELFGGGPNAFSRYERGSTEAPQPLVQLFKILGRHPELINELRAG

Nucleotide

• Length: 402 bp

>AT198164 NZ_CP096842:1687145-1687447 [Mycobacterium tuberculosis variant bovis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1H2LFQ3