Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1135958..1136597 Replicon chromosome
Accession NZ_CP072610
Organism Pseudomonas wenzhouensis strain A20

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag J7655_RS05170 Protein ID WP_230926864.1
Coordinates 1135958..1136272 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J7655_RS05175 Protein ID WP_230926865.1
Coordinates 1136265..1136597 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7655_RS05155 (J7655_05145) 1132259..1133188 + 930 WP_230926861.1 D-2-hydroxyacid dehydrogenase family protein -
J7655_RS05160 (J7655_05150) 1133362..1134306 + 945 WP_230926862.1 LysR family transcriptional regulator -
J7655_RS05165 (J7655_05155) 1134352..1135548 - 1197 WP_230926863.1 MFS transporter -
J7655_RS05170 (J7655_05160) 1135958..1136272 + 315 WP_230926864.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J7655_RS05175 (J7655_05165) 1136265..1136597 + 333 WP_230926865.1 XRE family transcriptional regulator Antitoxin
J7655_RS05180 (J7655_05170) 1137155..1138240 - 1086 WP_011913346.1 IS5-like element ISPst12 family transposase -
J7655_RS05185 (J7655_05175) 1138649..1138885 + 237 Protein_1021 transposase -
J7655_RS05190 (J7655_05180) 1139401..1140144 - 744 WP_230926866.1 cache domain-containing protein -
J7655_RS05195 (J7655_05185) 1140249..1141004 - 756 WP_230926867.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(2-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-73)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11909.13 Da        Isoelectric Point: 5.1828

>T198159 WP_230926864.1 NZ_CP072610:1135958-1136272 [Pseudomonas wenzhouensis]
MSAEEQESVAVSVQLLEERGPSLGFPHSSGINGSRHSHMRELRTQHEGRSYRTLYAFDPRRSAILLIDGDKTGDDRWYDI
NVPLSDRLYDEHLEQLRKEGLIDG

Download         Length: 315 bp

>T198159 NZ_CP096842:1240703-1241077 [Mycobacterium tuberculosis variant bovis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12254.24 Da        Isoelectric Point: 7.3202

>AT198159 WP_230926865.1 NZ_CP072610:1136265-1136597 [Pseudomonas wenzhouensis]
MAKKFAELRAKMAPEAQARVEAKAQELLAEMPLHELRQARGLSQKVLAEVLHVQQPSIAKMEKRTDIYISTLRSHIEAMG
GQLDVIARFPDGSVKISNFSDIESDLLLQA

Download         Length: 333 bp

>AT198159 NZ_CP096842:1240509-1240706 [Mycobacterium tuberculosis variant bovis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References