Detailed information of TA system TA198124

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1810378..1810587
• Replicon: chromosome
• Accession: NZ_CP072579
• Organism: Enterococcus faecium strain VB12993

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: J7299_RS15655
• Protein ID: WP_220482000.1
• Coordinates: 1810444..1810587 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1810378..1810464 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J7299_RS08865 (J7299_08865)	1806217..1806411	-	195	WP_085811488.1	hypothetical protein	-
J7299_RS08870 (J7299_08870)	1806411..1808975	-	2565	WP_085811487.1	trse protein	-
J7299_RS08875 (J7299_08875)	1809191..1809334	-	144	WP_220481999.1	putative holin-like toxin	-
J7299_RS08880 (J7299_08880)	1809411..1810106	-	696	WP_085811485.1	hypothetical protein	-
-	1810378..1810464	+	87	-	-	Antitoxin
J7299_RS15655	1810444..1810587	-	144	WP_220482000.1	putative holin-like toxin	Toxin
J7299_RS08890 (J7299_08890)	1810667..1811059	-	393	WP_085811484.1	DUF5592 family protein	-
J7299_RS08895 (J7299_08895)	1811071..1813200	-	2130	WP_085811483.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5088.10 Da
• Isoelectric Point: 10.3163

>T198124 WP_220482000.1 NZ_CP072579:c1810587-1810444 [Enterococcus faecium]
MEVSVHSLERRSLLSVAEALGLMISFGSLIATIIFGILTAVKNDKKK

Nucleotide

• Length: 144 bp

>T198124 NZ_CP096841:2835118-2835495 [Mycobacterium tuberculosis variant bovis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin

Nucleotide

• Length: 87 bp

>AT198124 NZ_CP072579:1810378-1810464 [Enterococcus faecium]
CCGCTTAAGACGGTGGCGACATTAGTTATATCTAAAAAATAACCGCTGACTCGCTAAAGTAGACGGTTATTTTTTCTTGT
CATTTTT

Structures

Antitoxin