Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 750080..750773 Replicon chromosome
Accession NZ_CP072564
Organism Escherichia coli strain WG5::PA2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag J8F87_RS03600 Protein ID WP_000415584.1
Coordinates 750080..750376 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag J8F87_RS03605 Protein ID WP_000650107.1
Coordinates 750378..750773 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8F87_RS03565 (745168) 745168..745482 - 315 WP_000958598.1 putative quinol monooxygenase -
J8F87_RS03570 (745513) 745513..746094 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
J8F87_RS03575 (746413) 746413..746745 + 333 WP_000917684.1 DUF2645 family protein -
J8F87_RS03580 (746791) 746791..748140 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
J8F87_RS03585 (748137) 748137..748796 - 660 WP_081508774.1 quorum sensing response regulator transcription factor QseB -
J8F87_RS03590 (748948) 748948..749340 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
J8F87_RS03595 (749393) 749393..749875 + 483 WP_000183505.1 GyrI-like domain-containing protein -
J8F87_RS03600 (750080) 750080..750376 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
J8F87_RS03605 (750378) 750378..750773 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
J8F87_RS03610 (750906) 750906..752513 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
J8F87_RS03615 (752651) 752651..754909 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T198051 WP_000415584.1 NZ_CP072564:750080-750376 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T198051 NZ_CP096840:1752796-1753200 [Mycobacterium tuberculosis variant bovis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT198051 WP_000650107.1 NZ_CP072564:750378-750773 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT198051 NZ_CP096840:1752587-1752790 [Mycobacterium tuberculosis variant bovis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References