Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3162366..3163141 Replicon chromosome
Accession NZ_CP072555
Organism Klebsiella pneumoniae strain KP2648

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag J7339_RS15595 Protein ID WP_004150910.1
Coordinates 3162656..3163141 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag J7339_RS15590 Protein ID WP_004150912.1
Coordinates 3162366..3162659 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7339_RS15570 (J7339_15515) 3157574..3158176 - 603 WP_062954968.1 short chain dehydrogenase -
J7339_RS15575 (J7339_15520) 3158274..3159185 + 912 WP_004188550.1 LysR family transcriptional regulator -
J7339_RS15580 (J7339_15525) 3159186..3160334 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
J7339_RS15585 (J7339_15530) 3160345..3161721 - 1377 WP_004217775.1 cystathionine beta-synthase -
J7339_RS15590 (J7339_15535) 3162366..3162659 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
J7339_RS15595 (J7339_15540) 3162656..3163141 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
J7339_RS15600 (J7339_15545) 3163845..3164438 + 594 WP_004188553.1 hypothetical protein -
J7339_RS15605 (J7339_15550) 3164535..3164751 + 217 Protein_3042 transposase -
J7339_RS15610 (J7339_15555) 3165357..3166229 + 873 WP_004188557.1 ParA family protein -
J7339_RS15615 (J7339_15560) 3166229..3166612 + 384 WP_004150906.1 hypothetical protein -
J7339_RS15620 (J7339_15565) 3166605..3167972 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3164535..3164687 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T198025 WP_004150910.1 NZ_CP072555:3162656-3163141 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T198025 NZ_CP096840:69406-69807 [Mycobacterium tuberculosis variant bovis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT198025 WP_004150912.1 NZ_CP072555:3162366-3162659 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT198025 NZ_CP096840:69174-69413 [Mycobacterium tuberculosis variant bovis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGTAATCGAGATCCTGGAAC
AAGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References