Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2004252..2004754 Replicon chromosome
Accession NZ_CP072539
Organism Escherichia coli O128ac:H12 strain AW1.7

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag J7886_RS09490 Protein ID WP_000767829.1
Coordinates 2004500..2004754 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag J7886_RS09485 Protein ID WP_001259255.1
Coordinates 2004252..2004503 (+) Length 84 a.a.

Genomic Context

J7886_RS09485J7886_RS09490J7886_RS09495J7886_RS09500J7886_RS09505J7886_RS09510J7886_RS09515J7886_RS09520J7886_RS09460J7886_RS09465J7886_RS09470J7886_RS09475J7886_RS09480
Location: 2004252..2004503 (252 bp)
Type: Antitoxin
Protein ID: WP_001259255.1
Location: 2004500..2004754 (255 bp)
Type: Toxin
Protein ID: WP_000767829.1
Location: 2004837..2005661 (825 bp)
Type: Others
Protein ID: WP_000754737.1
Location: 2005707..2006636 (930 bp)
Type: Others
Protein ID: WP_000803351.1
Location: 2006851..2006913 (63 bp)
Type: Others
Protein ID: WP_010723108.1
Location: 2006903..2008261 (1359 bp)
Type: Others
Protein ID: WP_000019197.1
Location: 2008440..2009498 (1059 bp)
Type: Others
Protein ID: WP_000492315.1
Location: 2009512..2009739 (228 bp)
Type: Others
Protein ID: WP_000985273.1
Location: 1999430..2000497 (1068 bp)
Type: Others
Protein ID: WP_054626082.1
Location: 2000497..2001567 (1071 bp)
Type: Others
Protein ID: WP_032151756.1
Location: 2001564..2002868 (1305 bp)
Type: Others
Protein ID: WP_032218856.1
Location: 2002874..2003773 (900 bp)
Type: Others
Protein ID: WP_000131782.1
Location: 2003919..2003969 (51 bp)
Type: Others
Protein ID: WP_001364200.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J7886_RS09460 (1999430)1999430..2000497-1068WP_054626082.1bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB-
J7886_RS09465 (2000497)2000497..2001567-1071WP_032151756.1histidinol-phosphate transaminase-
J7886_RS09470 (2001564)2001564..2002868-1305WP_032218856.1histidinol dehydrogenase-
J7886_RS09475 (2002874)2002874..2003773-900WP_000131782.1ATP phosphoribosyltransferase-
J7886_RS09480 (2003919)2003919..2003969-51WP_001364200.1his operon leader peptide-
J7886_RS09485 (2004252)2004252..2004503+252WP_001259255.1YoeB-YefM toxin-antitoxin system antitoxin YefMAntitoxin
J7886_RS09490 (2004500)2004500..2004754+255WP_000767829.1type II toxin-antitoxin system mRNA interferase toxin YoeBToxin
J7886_RS09495 (2004837)2004837..2005661+825WP_000754737.1SDR family oxidoreductase-
J7886_RS09500 (2005707)2005707..2006636+930WP_000803351.1LysR substrate-binding domain-containing protein-
J7886_RS09505 (2006851)2006851..2006913+63WP_010723108.1membrane protein YoeI-
J7886_RS09510 (2006903)2006903..2008261+1359WP_000019197.1putrescine/proton symporter PlaP-
J7886_RS09515 (2008440)2008440..2009498+1059WP_000492315.1thiosulfate utilization transporter TsuA/YeeE-
J7886_RS09520 (2009512)2009512..2009739+228WP_000985273.1thiosulfate utilization sulfurtransferase TsuB/YeeD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T197986 WP_000767829.1 NZ_CP072539:2004500-2004754 [Escherichia coli O128ac:H12]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T197986 NZ_CP096839:1165111-1165992 [Mycobacterium tuberculosis variant bovis]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCCATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT197986 WP_001259255.1 NZ_CP072539:2004252-2004503 [Escherichia coli O128ac:H12]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT197986 NZ_CP096839:1164491-1165114 [Mycobacterium tuberculosis variant bovis]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTACGCGCTCGGCCGAAGCGAGCATCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6NY6
PDB2A6S
PDB6OXA
PDB2A6R
PDB4V8X
PDB6OTR
PDB6OXI
PDB2A6Q

Antitoxin

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Source
ID
Structure
PDB2A6Q
AlphaFold DBA0A7U9LNR0

References