Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1218008..1218735 Replicon chromosome
Accession NZ_CP072539
Organism Escherichia coli O128ac:H12 strain AW1.7

Toxin (Protein)


Gene name higB Uniprot ID J7Q991
Locus tag J7886_RS05735 Protein ID WP_000547564.1
Coordinates 1218008..1218319 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J7886_RS05740 Protein ID WP_000126294.1
Coordinates 1218316..1218735 (+) Length 140 a.a.

Genomic Context

J7886_RS05705J7886_RS05710J7886_RS05715J7886_RS05720J7886_RS05725J7886_RS05730J7886_RS05735J7886_RS05740J7886_RS05755J7886_RS05760J7886_RS05745J7886_RS05750
Location: 1213150..1214859 (1710 bp)
Type: Others
Protein ID: WP_001288134.1
Location: 1214869..1215411 (543 bp)
Type: Others
Protein ID: WP_000493792.1
Location: 1215411..1216178 (768 bp)
Type: Others
Protein ID: WP_000067401.1
Location: 1216175..1216585 (411 bp)
Type: Others
Protein ID: WP_001291918.1
Location: 1216578..1217048 (471 bp)
Type: Others
Protein ID: WP_000132961.1
Location: 1217073..1217834 (762 bp)
Type: Others
Protein ID: WP_001026446.1
Location: 1218008..1218319 (312 bp)
Type: Toxin
Protein ID: WP_000547564.1
Location: 1218316..1218735 (420 bp)
Type: Antitoxin
Protein ID: WP_000126294.1
Location: 1221999..1223009 (1011 bp)
Type: Others
Protein ID: WP_001402444.1
Location: 1223158..1223685 (528 bp)
Type: Others
Protein ID: WP_001078777.1
Location: 1218849..1220273 (1425 bp)
Type: Others
Protein ID: WP_000110363.1
Location: 1220282..1221739 (1458 bp)
Type: Others
Protein ID: WP_001107882.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J7886_RS05705 (1213150)1213150..1214859+1710WP_001288134.1formate hydrogenlyase subunit HycE-
J7886_RS05710 (1214869)1214869..1215411+543WP_000493792.1formate hydrogenlyase subunit HycF-
J7886_RS05715 (1215411)1215411..1216178+768WP_000067401.1formate hydrogenlyase subunit HycG-
J7886_RS05720 (1216175)1216175..1216585+411WP_001291918.1formate hydrogenlyase assembly protein HycH-
J7886_RS05725 (1216578)1216578..1217048+471WP_000132961.1hydrogenase maturation peptidase HycI-
J7886_RS05730 (1217073)1217073..1217834+762WP_001026446.1hypothetical protein-
J7886_RS05735 (1218008)1218008..1218319+312WP_000547564.1type II toxin-antitoxin system HigB family toxinToxin
J7886_RS05740 (1218316)1218316..1218735+420WP_000126294.1helix-turn-helix domain-containing proteinAntitoxin
J7886_RS05745 (1218849)1218849..1220273-1425WP_000110363.16-phospho-beta-glucosidase AscB-
J7886_RS05750 (1220282)1220282..1221739-1458WP_001107882.1PTS cellobiose/arbutin/salicin transporter subunit IIBC-
J7886_RS05755 (1221999)1221999..1223009+1011WP_001402444.1DNA-binding transcriptional regulator AscG-
J7886_RS05760 (1223158)1223158..1223685+528WP_001078777.1electron transport protein HydN-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12426.13 Da        Isoelectric Point: 9.7248

>T197984 WP_000547564.1 NZ_CP072539:1218008-1218319 [Escherichia coli O128ac:H12]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFRYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

>T197984 NZ_CP096839:839989-840417 [Mycobacterium tuberculosis variant bovis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT197984 WP_000126294.1 NZ_CP072539:1218316-1218735 [Escherichia coli O128ac:H12]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT197984 NZ_CP096839:839708-839965 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0A0FJG5

Antitoxin

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Source
ID
Structure
No matching records found

References