Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 896240..896933 | Replicon | chromosome |
| Accession | NZ_CP072539 | ||
| Organism | Escherichia coli O128ac:H12 strain AW1.7 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | S1EZG2 |
| Locus tag | J7886_RS04190 | Protein ID | WP_000415584.1 |
| Coordinates | 896240..896536 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | S1EBV2 |
| Locus tag | J7886_RS04195 | Protein ID | WP_000650107.1 |
| Coordinates | 896538..896933 (+) | Length | 132 a.a. |
Genomic Context
Location: 891374..891853 (480 bp)
Type: Others
Protein ID: WP_000065333.1
Type: Others
Protein ID: WP_000065333.1
Location: 891856..892566 (711 bp)
Type: Others
Protein ID: WP_000834029.1
Type: Others
Protein ID: WP_000834029.1
Location: 892573..892905 (333 bp)
Type: Others
Protein ID: WP_000914691.1
Type: Others
Protein ID: WP_000914691.1
Location: 895108..895500 (393 bp)
Type: Others
Protein ID: WP_000712658.1
Type: Others
Protein ID: WP_000712658.1
Location: 895553..896035 (483 bp)
Type: Others
Protein ID: WP_054625966.1
Type: Others
Protein ID: WP_054625966.1
Location: 896240..896536 (297 bp)
Type: Toxin
Protein ID: WP_000415584.1
Type: Toxin
Protein ID: WP_000415584.1
Location: 896538..896933 (396 bp)
Type: Antitoxin
Protein ID: WP_000650107.1
Type: Antitoxin
Protein ID: WP_000650107.1
Location: 897066..898673 (1608 bp)
Type: Others
Protein ID: WP_001295629.1
Type: Others
Protein ID: WP_001295629.1
Location: 898811..901069 (2259 bp)
Type: Others
Protein ID: WP_001281881.1
Type: Others
Protein ID: WP_001281881.1
Location: 892951..894300 (1350 bp)
Type: Others
Protein ID: WP_000673402.1
Type: Others
Protein ID: WP_000673402.1
Location: 894297..894956 (660 bp)
Type: Others
Protein ID: WP_054625965.1
Type: Others
Protein ID: WP_054625965.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J7886_RS25115 (891374) | 891374..891853 | + | 480 | WP_000065333.1 | Hcp family type VI secretion system effector | - |
| J7886_RS25120 (891856) | 891856..892566 | + | 711 | WP_000834029.1 | hypothetical protein | - |
| J7886_RS04165 (892573) | 892573..892905 | + | 333 | WP_000914691.1 | DUF2645 family protein | - |
| J7886_RS04170 (892951) | 892951..894300 | - | 1350 | WP_000673402.1 | quorum sensing histidine kinase QseC | - |
| J7886_RS04175 (894297) | 894297..894956 | - | 660 | WP_054625965.1 | quorum sensing response regulator transcription factor QseB | - |
| J7886_RS04180 (895108) | 895108..895500 | + | 393 | WP_000712658.1 | OB fold stress tolerance protein YgiW | - |
| J7886_RS04185 (895553) | 895553..896035 | + | 483 | WP_054625966.1 | GyrI-like domain-containing protein | - |
| J7886_RS04190 (896240) | 896240..896536 | + | 297 | WP_000415584.1 | type II toxin-antitoxin system toxin MqsR | Toxin |
| J7886_RS04195 (896538) | 896538..896933 | + | 396 | WP_000650107.1 | type II toxin-antitoxin system antitoxin MqsA | Antitoxin |
| J7886_RS04200 (897066) | 897066..898673 | + | 1608 | WP_001295629.1 | ABC transporter substrate-binding protein | - |
| J7886_RS04205 (898811) | 898811..901069 | + | 2259 | WP_001281881.1 | DNA topoisomerase IV subunit A | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11231.96 Da Isoelectric Point: 8.9070
>T197981 WP_000415584.1 NZ_CP072539:896240-896536 [Escherichia coli O128ac:H12]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
Download Length: 297 bp
>T197981 NZ_CP096839:c753427-753119 [Mycobacterium tuberculosis variant bovis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14703.10 Da Isoelectric Point: 9.2136
>AT197981 WP_000650107.1 NZ_CP072539:896538-896933 [Escherichia coli O128ac:H12]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Download Length: 396 bp
>AT197981 NZ_CP096839:c753659-753414 [Mycobacterium tuberculosis variant bovis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA