Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 896240..896933 Replicon chromosome
Accession NZ_CP072539
Organism Escherichia coli O128ac:H12 strain AW1.7

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag J7886_RS04190 Protein ID WP_000415584.1
Coordinates 896240..896536 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag J7886_RS04195 Protein ID WP_000650107.1
Coordinates 896538..896933 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7886_RS25115 (891374) 891374..891853 + 480 WP_000065333.1 Hcp family type VI secretion system effector -
J7886_RS25120 (891856) 891856..892566 + 711 WP_000834029.1 hypothetical protein -
J7886_RS04165 (892573) 892573..892905 + 333 WP_000914691.1 DUF2645 family protein -
J7886_RS04170 (892951) 892951..894300 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
J7886_RS04175 (894297) 894297..894956 - 660 WP_054625965.1 quorum sensing response regulator transcription factor QseB -
J7886_RS04180 (895108) 895108..895500 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
J7886_RS04185 (895553) 895553..896035 + 483 WP_054625966.1 GyrI-like domain-containing protein -
J7886_RS04190 (896240) 896240..896536 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
J7886_RS04195 (896538) 896538..896933 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
J7886_RS04200 (897066) 897066..898673 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
J7886_RS04205 (898811) 898811..901069 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T197981 WP_000415584.1 NZ_CP072539:896240-896536 [Escherichia coli O128ac:H12]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T197981 NZ_CP096839:c753427-753119 [Mycobacterium tuberculosis variant bovis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT197981 WP_000650107.1 NZ_CP072539:896538-896933 [Escherichia coli O128ac:H12]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT197981 NZ_CP096839:c753659-753414 [Mycobacterium tuberculosis variant bovis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References