Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 829861..830588 | Replicon | chromosome |
| Accession | NZ_CP072539 | ||
| Organism | Escherichia coli O128ac:H12 strain AW1.7 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U9ZMR4 |
| Locus tag | J7886_RS03870 | Protein ID | WP_000550189.1 |
| Coordinates | 829861..830175 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | J7886_RS03875 | Protein ID | WP_000560266.1 |
| Coordinates | 830172..830588 (+) | Length | 139 a.a. |
Genomic Context
Location: 828440..829576 (1137 bp)
Type: Others
Protein ID: WP_000018697.1
Type: Others
Protein ID: WP_000018697.1
Location: 829861..830175 (315 bp)
Type: Toxin
Protein ID: WP_000550189.1
Type: Toxin
Protein ID: WP_000550189.1
Location: 830172..830588 (417 bp)
Type: Antitoxin
Protein ID: WP_000560266.1
Type: Antitoxin
Protein ID: WP_000560266.1
Location: 826027..827013 (987 bp)
Type: Others
Protein ID: WP_001301393.1
Type: Others
Protein ID: WP_001301393.1
Location: 827092..827775 (684 bp)
Type: Others
Protein ID: WP_001183040.1
Type: Others
Protein ID: WP_001183040.1
Location: 827852..828355 (504 bp)
Type: Others
Protein ID: WP_001295542.1
Type: Others
Protein ID: WP_001295542.1
Location: 830633..832651 (2019 bp)
Type: Others
Protein ID: WP_000121421.1
Type: Others
Protein ID: WP_000121421.1
Location: 832977..835328 (2352 bp)
Type: Others
Protein ID: WP_000695498.1
Type: Others
Protein ID: WP_000695498.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J7886_RS03850 (826027) | 826027..827013 | - | 987 | WP_001301393.1 | Gfo/Idh/MocA family oxidoreductase | - |
| J7886_RS03855 (827092) | 827092..827775 | - | 684 | WP_001183040.1 | vancomycin high temperature exclusion protein | - |
| J7886_RS03860 (827852) | 827852..828355 | - | 504 | WP_001295542.1 | M48 family metallopeptidase | - |
| J7886_RS03865 (828440) | 828440..829576 | + | 1137 | WP_000018697.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
| J7886_RS03870 (829861) | 829861..830175 | + | 315 | WP_000550189.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| J7886_RS03875 (830172) | 830172..830588 | + | 417 | WP_000560266.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| J7886_RS03880 (830633) | 830633..832651 | - | 2019 | WP_000121421.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
| J7886_RS03885 (832977) | 832977..835328 | - | 2352 | WP_000695498.1 | alpha-glucosidase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12103.10 Da Isoelectric Point: 10.0409
>T197980 WP_000550189.1 NZ_CP072539:829861-830175 [Escherichia coli O128ac:H12]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T197980 NZ_CP072539:829861-830175 [Escherichia coli O128ac:H12]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 139 a.a. Molecular weight: 14995.42 Da Isoelectric Point: 4.4547
>AT197980 WP_000560266.1 NZ_CP072539:830172-830588 [Escherichia coli O128ac:H12]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT197980 NZ_CP072539:830172-830588 [Escherichia coli O128ac:H12]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCAAAAATAACCGCGTGGGAAGAATCTGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCAAAAATAACCGCGTGGGAAGAATCTGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA