Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 785121..785920 Replicon chromosome
Accession NZ_CP072539
Organism Escherichia coli O128ac:H12 strain AW1.7

Toxin (Protein)


Gene name yhaV Uniprot ID D7XZ20
Locus tag J7886_RS03640 Protein ID WP_000347264.1
Coordinates 785121..785585 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag J7886_RS03645 Protein ID WP_001307405.1
Coordinates 785585..785920 (-) Length 112 a.a.

Genomic Context

J7886_RS03635J7886_RS03655J7886_RS03660J7886_RS03610J7886_RS03615J7886_RS03620J7886_RS03625J7886_RS03630J7886_RS03640J7886_RS03645J7886_RS03650
Location: 784257..785066 (810 bp)
Type: Others
Protein ID: WP_000072187.1
Location: 788015..789349 (1335 bp)
Type: Others
Protein ID: WP_054625915.1
Location: 789365..790135 (771 bp)
Type: Others
Protein ID: WP_001058209.1
Location: 780122..780556 (435 bp)
Type: Others
Protein ID: WP_000948824.1
Location: 780574..781452 (879 bp)
Type: Others
Protein ID: WP_001300474.1
Location: 781442..782221 (780 bp)
Type: Others
Protein ID: WP_000406214.1
Location: 782232..782705 (474 bp)
Type: Others
Protein ID: WP_001295547.1
Location: 782728..784008 (1281 bp)
Type: Others
Protein ID: WP_054625916.1
Location: 785121..785585 (465 bp)
Type: Toxin
Protein ID: WP_000347264.1
Location: 785585..785920 (336 bp)
Type: Antitoxin
Protein ID: WP_001307405.1
Location: 786069..787640 (1572 bp)
Type: Others
Protein ID: WP_001273753.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J7886_RS03610 (780122)780122..780556-435WP_000948824.1PTS galactosamine/N-acetylgalactosamine transporter subunit IIA-
J7886_RS03615 (780574)780574..781452-879WP_001300474.1PTS N-acetylgalactosamine transporter subunit IID-
J7886_RS03620 (781442)781442..782221-780WP_000406214.1PTS N-acetylgalactosamine transporter subunit IIC-
J7886_RS03625 (782232)782232..782705-474WP_001295547.1PTS N-acetylgalactosamine transporter subunit IIB-
J7886_RS03630 (782728)782728..784008-1281WP_054625916.1tagatose-bisphosphate aldolase subunit KbaZ-
J7886_RS03635 (784257)784257..785066+810WP_000072187.1aga operon transcriptional regulator AgaR-
J7886_RS03640 (785121)785121..785585-465WP_000347264.1type II toxin-antitoxin system ribonuclease toxin YhaVToxin
J7886_RS03645 (785585)785585..785920-336WP_001307405.1type II toxin-antitoxin system antitoxin PrlFAntitoxin
J7886_RS03650 (786069)786069..787640-1572WP_001273753.1galactarate dehydratase-
J7886_RS03655 (788015)788015..789349+1335WP_054625915.1galactarate/glucarate/glycerate transporter GarP-
J7886_RS03660 (789365)789365..790135+771WP_001058209.12-dehydro-3-deoxyglucarate aldolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17894.29 Da        Isoelectric Point: 9.4945

>T197979 WP_000347264.1 NZ_CP072539:c785585-785121 [Escherichia coli O128ac:H12]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFDAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T197979 NZ_CP096839:716193-716600 [Mycobacterium tuberculosis variant bovis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT197979 WP_001307405.1 NZ_CP072539:c785920-785585 [Escherichia coli O128ac:H12]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT197979 NZ_CP096839:715936-716196 [Mycobacterium tuberculosis variant bovis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A241QML2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E0XVC7

References