Detailed information of TA system TA197939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1290049..1290563
• Replicon: chromosome
• Accession: NZ_CP072504
• Organism: Bifidobacterium pseudocatenulatum strain N2

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: J7M37_RS05540
• Protein ID: WP_055054685.1
• Coordinates: 1290049..1290303 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A3E5ATR4
• Locus tag: J7M37_RS05545
• Protein ID: WP_065440807.1
• Coordinates: 1290303..1290563 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J7M37_RS05530 (J7M37_05530)	1286337..1288532	+	2196	WP_226845991.1	type IA DNA topoisomerase	-
J7M37_RS05535 (J7M37_05535)	1288950..1289846	+	897	WP_117656661.1	Fic family protein	-
J7M37_RS09590	1289934..1290062	-	129	WP_270201072.1	hypothetical protein	-
J7M37_RS05540 (J7M37_05540)	1290049..1290303	-	255	WP_055054685.1	Txe/YoeB family addiction module toxin	Toxin
J7M37_RS05545 (J7M37_05545)	1290303..1290563	-	261	WP_065440807.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J7M37_RS05550 (J7M37_05550)	1290823..1291095	+	273	WP_118765406.1	hypothetical protein	-
J7M37_RS05555 (J7M37_05555)	1291368..1291685	-	318	WP_209107201.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1284096..1324097	40001

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10013.51 Da
• Isoelectric Point: 7.9920

>T197939 WP_055054685.1 NZ_CP072504:c1290303-1290049 [Bifidobacterium pseudocatenulatum]
IMLRWTDDAWNDYLYWQVQDKKTLKRVNALIRDAMRSPFAGLGKPEPLKWELQGAWSRRIDSANRLVYMIEDGDLCILSV
RDHY

Nucleotide

• Length: 255 bp

>T197939 NZ_CP096834:3633134-3633541 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9702.90 Da
• Isoelectric Point: 4.7241

>AT197939 WP_065440807.1 NZ_CP072504:c1290563-1290303 [Bifidobacterium pseudocatenulatum]
MVTAVAYTNFRKDLKSYLRRVNDDADMLLITNKDPGDNVVVMSADDYDSLMETLRVYQNPGLFDKVRRGMAQVRSGSTDS
HDLVGE

Nucleotide

• Length: 261 bp

>AT197939 NZ_CP096834:3632887-3633153 [Escherichia coli]
ATGGACATTAATAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3E5ATR4