Detailed information of TA system TA197873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 3990443..3991040
• Replicon: chromosome
• Accession: NZ_CP072468
• Organism: Klebsiella quasipneumoniae strain B6885

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: J6315_RS19475
• Protein ID: WP_049013659.1
• Coordinates: 3990723..3991040 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: J6315_RS19470
• Protein ID: WP_049013658.1
• Coordinates: 3990443..3990730 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6315_RS19440 (3986631)	3986631..3986879	+	249	WP_002893037.1	DUF1158 domain-containing protein	-
J6315_RS19445 (3986897)	3986897..3987238	-	342	WP_004202492.1	RamA family antibiotic efflux transcriptional regulator	-
J6315_RS19450 (3987269)	3987269..3988384	-	1116	WP_162543091.1	MBL fold metallo-hydrolase	-
J6315_RS19455 (3988564)	3988564..3989148	+	585	WP_023288732.1	TetR/AcrR family transcriptional regulator	-
J6315_RS19460 (3989145)	3989145..3989513	+	369	WP_004202487.1	MmcQ/YjbR family DNA-binding protein	-
J6315_RS19465 (3989633)	3989633..3990286	+	654	WP_023288731.1	oxygen-insensitive NAD(P)H nitroreductase	-
J6315_RS19470 (3990443)	3990443..3990730	-	288	WP_049013658.1	helix-turn-helix transcriptional regulator	Antitoxin
J6315_RS19475 (3990723)	3990723..3991040	-	318	WP_049013659.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J6315_RS19480 (3991225)	3991225..3992268	-	1044	WP_109546575.1	DUF2157 domain-containing protein	-
J6315_RS19485 (3992614)	3992614..3993480	-	867	WP_117140809.1	helix-turn-helix transcriptional regulator	-
J6315_RS19490 (3993589)	3993589..3995016	+	1428	WP_048296961.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-100)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-88)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12102.38 Da
• Isoelectric Point: 11.2767

>T197873 WP_049013659.1 NZ_CP072468:c3991040-3990723 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Nucleotide

• Length: 318 bp

>T197873 NZ_CP096811:c144807-144325 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGCAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10810.49 Da
• Isoelectric Point: 10.2213

>AT197873 WP_049013658.1 NZ_CP072468:c3990730-3990443 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Nucleotide

• Length: 288 bp

>AT197873 NZ_CP096811:c145061-144795 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA