Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1118123..1118622 Replicon chromosome
Accession NZ_CP072467
Organism Spiractinospora alimapuensis strain VN6-2

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag J4H86_RS05180 Protein ID WP_236542364.1
Coordinates 1118365..1118622 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag J4H86_RS05175 Protein ID WP_236542363.1
Coordinates 1118123..1118368 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4H86_RS05145 (J4H86_05120) 1113669..1114604 + 936 WP_236542358.1 aldose 1-epimerase family protein -
J4H86_RS05150 (J4H86_05125) 1114601..1115563 - 963 WP_236542359.1 immunity 49 family protein -
J4H86_RS05155 (J4H86_05130) 1115647..1116282 - 636 WP_236542360.1 pyridoxamine 5'-phosphate oxidase family protein -
J4H86_RS05160 (J4H86_05135) 1116396..1116647 - 252 WP_236542361.1 DUF397 domain-containing protein -
J4H86_RS05165 (J4H86_05140) 1116644..1117495 - 852 WP_269134574.1 helix-turn-helix transcriptional regulator -
J4H86_RS05170 (J4H86_05145) 1117702..1117959 + 258 WP_236542362.1 hypothetical protein -
J4H86_RS05175 (J4H86_05150) 1118123..1118368 + 246 WP_236542363.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J4H86_RS05180 (J4H86_05155) 1118365..1118622 + 258 WP_236542364.1 Txe/YoeB family addiction module toxin Toxin
J4H86_RS05185 (J4H86_05160) 1118628..1119218 - 591 WP_236542365.1 nucleotidyltransferase family protein -
J4H86_RS05190 (J4H86_05165) 1119215..1120339 - 1125 WP_236542366.1 XdhC family protein -
J4H86_RS05195 (J4H86_05170) 1120355..1121539 - 1185 WP_236542367.1 VWA domain-containing protein -
J4H86_RS05200 (J4H86_05175) 1121542..1122495 - 954 WP_236542368.1 MoxR family ATPase -
J4H86_RS05205 (J4H86_05180) 1122922..1123347 - 426 WP_236543910.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-71)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10142.44 Da        Isoelectric Point: 6.6433

>T197861 WP_236542364.1 NZ_CP072467:1118365-1118622 [Spiractinospora alimapuensis]
VRVVFTPHGWEDYTHWLSADRSTLKRINRLIDDILRDPFEGIGKPEPLRHAFAGAWSRRISEEHRLVYLVDDEDIVILQA
RYHYN

Download         Length: 258 bp

>T197861 NZ_CP096810:c3207908-3206586 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTAACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCTAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCTATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9215.34 Da        Isoelectric Point: 6.0850

>AT197861 WP_236542363.1 NZ_CP072467:1118123-1118368 [Spiractinospora alimapuensis]
MAITASEARKHLFPLIEKVNDDRAPVEITSRRGDAVLISKEDYEALEETAHLLRSPANARRLLESLAQARRDERHEHSLA
E

Download         Length: 246 bp

>AT197861 NZ_CP096810:c3208174-3207908 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACATGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References