Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4361175..4361746 Replicon chromosome
Accession NZ_CP072455
Organism Xenorhabdus budapestensis strain C-7-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HGO23_RS19880 Protein ID WP_280529549.1
Coordinates 4361175..4361333 (+) Length 53 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HGO23_RS19455 Protein ID WP_244967851.1
Coordinates 4361417..4361746 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO23_RS19440 (HGO23_19440) 4357200..4360151 + 2952 WP_209027545.1 TonB-dependent receptor -
HGO23_RS19445 (HGO23_19445) 4360160..4360975 + 816 WP_209027546.1 energy transducer TonB -
HGO23_RS19880 (HGO23_19450) 4361175..4361333 + 159 WP_280529549.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGO23_RS19455 (HGO23_19455) 4361417..4361746 + 330 WP_244967851.1 HigA family addiction module antitoxin Antitoxin
HGO23_RS19460 (HGO23_19460) 4361893..4363257 - 1365 WP_209027547.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
HGO23_RS19465 (HGO23_19465) 4363350..4364981 - 1632 WP_209027548.1 membrane protein insertase YidC -
HGO23_RS19470 (HGO23_19470) 4364984..4365244 - 261 WP_099136768.1 membrane protein insertion efficiency factor YidD -
HGO23_RS19475 (HGO23_19475) 4365208..4365567 - 360 WP_099136767.1 ribonuclease P protein component -
HGO23_RS19480 (HGO23_19480) 4365585..4365725 - 141 WP_038267117.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-52)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5910.75 Da        Isoelectric Point: 8.0214

>T197788 WP_280529549.1 NZ_CP072455:4361175-4361333 [Xenorhabdus budapestensis]
IPSTIEGVLFRKLQILDAATQESDLRIPPGNRFEHLQGNLSGWCSIRVNKQY

Download         Length: 159 bp

>T197788 NZ_CP096715:3226-3582 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAGCAACACAAGAGAAAGTCTTAGC
TGCATTGGTTGTTCTACAACAGCAAGGGCCTAGTTTAGGTCGTCCTTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGTGGTAAACCGTTAAGGGCATTTTTTGCATTCGATCCCCTAAGACAAGCGATT
GTGCTGTGTATTGGTGATAAGAGTAATAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATGAGCAATACGCACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12524.45 Da        Isoelectric Point: 8.7254

>AT197788 WP_244967851.1 NZ_CP072455:4361417-4361746 [Xenorhabdus budapestensis]
MRNTKRRPVTVGQMLVTEFLEPMNIEISELAEAMGVHRNTLSRIVHDKGNLTASMAIKLAVALGNTPEFWLNIQHAVELW
DVRHKAYEQEAKNVKQVRPHLEHSEVAFR

Download         Length: 330 bp

>AT197788 NZ_CP096715:3575-3877 [Acinetobacter baumannii]
ATGGCTAAGAGCTTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTTTTAGAAAGTCAGCTTCACCTTATCCGAGAAGAGTTAGAAATTTCCCAGAAAGAACTAGCTGCAACCCTTGGAATTA
AACAGCCGTCATTATCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGTGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGGTTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References