Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 960165..960763 Replicon chromosome
Accession NZ_CP072455
Organism Xenorhabdus budapestensis strain C-7-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HGO23_RS04310 Protein ID WP_187650600.1
Coordinates 960443..960763 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HGO23_RS04305 Protein ID WP_209028081.1
Coordinates 960165..960446 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO23_RS04280 (HGO23_04280) 956360..956674 + 315 WP_209028077.1 hypothetical protein -
HGO23_RS04285 (HGO23_04285) 956676..957356 + 681 WP_209028078.1 hypothetical protein -
HGO23_RS04290 (HGO23_04290) 957511..958629 + 1119 WP_244967946.1 phage tail protein -
HGO23_RS04295 (HGO23_04295) 958678..959544 - 867 WP_209028080.1 phage tail protein -
HGO23_RS04300 (HGO23_04300) 959842..960125 + 284 Protein_848 helix-turn-helix transcriptional regulator -
HGO23_RS04305 (HGO23_04305) 960165..960446 - 282 WP_209028081.1 helix-turn-helix transcriptional regulator Antitoxin
HGO23_RS04310 (HGO23_04310) 960443..960763 - 321 WP_187650600.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGO23_RS04315 (HGO23_04315) 961145..962302 - 1158 WP_209028082.1 site-specific integrase -
HGO23_RS04320 (HGO23_04320) 962697..963092 - 396 WP_209028083.1 hypothetical protein -
HGO23_RS04325 (HGO23_04325) 963369..963980 - 612 WP_209028084.1 XRE family transcriptional regulator -
HGO23_RS04330 (HGO23_04330) 964163..964399 + 237 WP_209028087.1 YdaS family helix-turn-helix protein -
HGO23_RS04335 (HGO23_04335) 964467..965249 + 783 WP_209028089.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 910691..1142970 232279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-86)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12056.16 Da        Isoelectric Point: 9.7884

>T197781 WP_187650600.1 NZ_CP072455:c960763-960443 [Xenorhabdus budapestensis]
MSWNIDFYHGVMDSILDMPPKIQARMLKLLELMEQHGANLGSPHTEPMGNGLFEVRAKAQEGIGRGLFCYLDGSHIYILH
AFVKKSQKTPKKDLDLAKSRMKEVKK

Download         Length: 321 bp

>T197781 NZ_CP096707:1613821-1614003 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10592.98 Da        Isoelectric Point: 8.9375

>AT197781 WP_209028081.1 NZ_CP072455:c960446-960165 [Xenorhabdus budapestensis]
MSQLQALKAKALQNPEVKQAYDELNDEFEFINTLLSMRTEAKLTQQQVADRMGTKESNISRLEKGKSNPTLSTLVNYAKA
CGFQLDFSYRRNS

Download         Length: 282 bp

>AT197781 NZ_CP096707:1614096-1614500 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References