Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1066563..1067155 Replicon chromosome
Accession NZ_CP072453
Organism Providencia sp. R33

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J6836_RS04915 Protein ID WP_219247325.1
Coordinates 1066877..1067155 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J6836_RS04910 Protein ID WP_219247323.1
Coordinates 1066563..1066877 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6836_RS04885 (J6836_04890) 1062375..1062719 + 345 WP_219247315.1 hypothetical protein -
J6836_RS04890 (J6836_04895) 1062845..1063417 - 573 WP_219247317.1 elongation factor P-like protein YeiP -
J6836_RS04895 (J6836_04900) 1063575..1064819 - 1245 WP_219247319.1 tryptophan permease -
J6836_RS04900 (J6836_04905) 1064971..1065408 - 438 WP_219247321.1 NUDIX domain-containing protein -
J6836_RS04905 (J6836_04910) 1065574..1066509 + 936 WP_219249385.1 1-phosphofructokinase -
J6836_RS04910 (J6836_04915) 1066563..1066877 - 315 WP_219247323.1 HigA family addiction module antitoxin Antitoxin
J6836_RS04915 (J6836_04920) 1066877..1067155 - 279 WP_219247325.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J6836_RS04920 (J6836_04925) 1067272..1068117 - 846 WP_219247326.1 deoxyribonuclease IV -
J6836_RS04925 (J6836_04930) 1068218..1069297 - 1080 WP_219247328.1 YeiH family protein -
J6836_RS04930 (J6836_04935) 1069489..1070352 + 864 WP_219247330.1 DNA-binding transcriptional regulator YeiE -
J6836_RS04935 (J6836_04940) 1070621..1072111 + 1491 WP_219247332.1 amino acid permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10716.18 Da        Isoelectric Point: 7.3172

>T197772 WP_219247325.1 NZ_CP072453:c1067155-1066877 [Providencia sp. R33]
MIKSFKHKGLKQLFEKGTLSGVSPKDTSRINDRLQAIDSANFIDDLDIFTFNLHQLKGDRVNIWSITVRANWRITFEFIN
GDAYILNLEDYH

Download         Length: 279 bp

>T197772 NZ_CP096696:450963-451352 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11462.19 Da        Isoelectric Point: 7.2001

>AT197772 WP_219247323.1 NZ_CP072453:c1066877-1066563 [Providencia sp. R33]
MKQATVTHPGIMVANILDDLGVGVRQFARNIGVTPATVSRFLSGKTALTPALAIRISAALGSNPEFWLRLQTHYDLRLLE
DKIDISGIVLYENLQQPQQPTSEY

Download         Length: 315 bp

>AT197772 NZ_CP096696:450699-450956 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References