Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 23394..24068 | Replicon | plasmid p1B33769 |
| Accession | NZ_CP072423 | ||
| Organism | Klebsiella pneumoniae strain B33769 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5Q9LMS5 |
| Locus tag | J6255_RS25680 | Protein ID | WP_032720638.1 |
| Coordinates | 23745..24068 (-) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | J6255_RS25675 | Protein ID | WP_032720637.1 |
| Coordinates | 23394..23696 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6255_RS25635 (J6255_25630) | 18587..19159 | + | 573 | WP_044266753.1 | hypothetical protein | - |
| J6255_RS25640 (J6255_25635) | 19190..19684 | + | 495 | WP_044266755.1 | hypothetical protein | - |
| J6255_RS25645 (J6255_25640) | 19987..20907 | + | 921 | WP_050548604.1 | TauD/TfdA family dioxygenase | - |
| J6255_RS25650 (J6255_25645) | 20919..21731 | + | 813 | WP_223203129.1 | TSUP family transporter | - |
| J6255_RS25655 (J6255_25650) | 21733..22305 | + | 573 | WP_032720635.1 | GNAT family N-acetyltransferase | - |
| J6255_RS25660 (J6255_25655) | 22410..22793 | + | 384 | WP_032720636.1 | hypothetical protein | - |
| J6255_RS25665 (J6255_25660) | 22790..22996 | + | 207 | WP_153591439.1 | hypothetical protein | - |
| J6255_RS25670 (J6255_25665) | 23184..23351 | + | 168 | WP_153591440.1 | hypothetical protein | - |
| J6255_RS25675 (J6255_25670) | 23394..23696 | - | 303 | WP_032720637.1 | NadS family protein | Antitoxin |
| J6255_RS25680 (J6255_25675) | 23745..24068 | - | 324 | WP_032720638.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J6255_RS25685 (J6255_25680) | 24246..24651 | - | 406 | Protein_28 | DUF4113 domain-containing protein | - |
| J6255_RS26535 | 24629..25056 | + | 428 | Protein_29 | DNA-binding protein | - |
| J6255_RS25690 (J6255_25685) | 25125..25727 | - | 603 | Protein_30 | RNA-guided endonuclease TnpB family protein | - |
| J6255_RS25695 (J6255_25690) | 26228..26551 | - | 324 | WP_019725650.1 | hypothetical protein | - |
| J6255_RS25700 (J6255_25695) | 26624..27619 | - | 996 | WP_019725651.1 | hypothetical protein | - |
| J6255_RS25705 (J6255_25700) | 27916..28566 | - | 651 | WP_015065500.1 | SOS response-associated peptidase | - |
| J6255_RS25710 (J6255_25705) | 28613..29011 | - | 399 | Protein_34 | recombinase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-15 / dfrA14 / qnrB1 / tet(A) / aac(6')-Ib-cr / blaOXA-1 / aac(3)-IIa | - | 1..137142 | 137142 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12372.29 Da Isoelectric Point: 9.6240
>T197766 WP_032720638.1 NZ_CP072423:c24068-23745 [Klebsiella pneumoniae]
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK
Download Length: 324 bp
>T197766 NZ_CP096691:c12217-11858 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11211.12 Da Isoelectric Point: 7.3611
>AT197766 WP_032720637.1 NZ_CP072423:c23696-23394 [Klebsiella pneumoniae]
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV
Download Length: 303 bp
>AT197766 NZ_CP096691:c11858-11559 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|