Detailed information of TA system TA197688

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4994033..4994454
• Replicon: chromosome
• Accession: NZ_CP072393
• Organism: Xanthomonas phaseoli pv. phaseoli strain 6546R(delta)tal18H

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3Q9Q4S9
• Locus tag: J6335_RS21580
• Protein ID: WP_017156024.1
• Coordinates: 4994341..4994454 (-)
• Length: 38 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: J6335_RS21575
• Protein ID: WP_017156025.1
• Coordinates: 4994033..4994323 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6335_RS21550 (J6335_21550)	4989368..4989700	+	333	WP_003482333.1	hypothetical protein	-
J6335_RS21560 (J6335_21560)	4990015..4991940	+	1926	WP_039574551.1	M61 family metallopeptidase	-
J6335_RS21565 (J6335_21565)	4992008..4992187	+	180	WP_039574549.1	hypothetical protein	-
J6335_RS21570 (J6335_21570)	4992290..4993678	-	1389	WP_039574546.1	type III secretion system effector XopQ	-
J6335_RS21575 (J6335_21575)	4994033..4994323	-	291	WP_017156025.1	HigA family addiction module antitoxin	Antitoxin
J6335_RS21580 (J6335_21580)	4994341..4994454	-	114	WP_017156024.1	hypothetical protein	Toxin
J6335_RS22715	4994451..4994624	-	174	WP_201443182.1	hypothetical protein	-
J6335_RS21585 (J6335_21585)	4994719..4997226	-	2508	WP_046834789.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4945609..5018362	72753

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-94)

Sequences

Toxin

Protein

• Length: 38 a.a.
• Molecular weight: 4677.41 Da
• Isoelectric Point: 9.1273

>T197688 WP_017156024.1 NZ_CP072393:c4994454-4994341 [Xanthomonas phaseoli pv. phaseoli]
MKGERRGQYRIRINDRWRICVRWMEGDVVQVEIIDYH

Nucleotide

• Length: 114 bp

>T197688 NZ_CP096583:c452869-452300 [Rhodococcus pyridinivorans]
ATGAGGCGTCTGGATCTGATCGTCGGTCCCAACGGTTCCGGCAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGCGCAGCGTGTTCGTCAATGCGGATGTGATCGCGCAGCAGCGCTGGCCCGACCGGGCGGAGGAGATGTCGTACGAGG
CGGCGCAGCTCGCCGCGGCGGCGCGGGACCGGTTGCTGCGGCAGGGCCGGTCGTTCATTGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGTTGATCGACCGCGCGCACGAGGTGGGGTTCACGGTGGTGCTGCACGTGATGCTGGTGCCCGAGGC
GATGTCGGTGCTGCGTGTACAGCACCGGGTGGCCTCCGGTGGGCATGCGGTGCCCGAGGACAAGATCCGGGCGCGTTATC
GGCGGTTGTGGCCGCTGGTGGCCGAAGCGATCGGCCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGTGCCGGTGGGTGCGGTGCGCTGGCCGGGATGGGCGCCGGCGGCGCTCACCGG
GCTCGGCTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10387.09 Da
• Isoelectric Point: 9.0188

>AT197688 WP_017156025.1 NZ_CP072393:c4994323-4994033 [Xanthomonas phaseoli pv. phaseoli]
MTVLPNIHPGAILLEEFLQPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTFERFWLGLQADDELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT197688 NZ_CP096583:c453252-452866 [Rhodococcus pyridinivorans]
ATGACGTCATCCACCGACAAGGTCACCCGCTTCGACGCCGAACTCGTCGACAGCGCCATCGCCGAGGGTGGCCGCCAGAA
CCGCACCGGACGCCAGCAACTCGAATACTGGGCCCGCATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCCCTGCACC
GGGTGCACGAGGCGCTGGCCGGGACACGGGAGCTGAGCGAGCTCACCGCCGCCGAGGGACGGCTGTTCGACGCGGAGATC
GATGCGCGCCTGGCGGACGGGCTGGCCCGCACCGACTACGCCGAGGTTCTCGCCGCGCGTGGGGTCAGCACGGTGGTGCT
CGACGACGAAGGCCGGCTGGTCGAGCAGCGTCCCGACGGTAGTCGCCGGGTGCTCGACGACGCATGA

Structures

Toxin

• AlphaFold DB: A0A3Q9Q4S9