Detailed information of TA system TA197678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2924090..2924600
• Replicon: chromosome
• Accession: NZ_CP072385
• Organism: Arachnia propionica strain F0714

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3N4CWJ0
• Locus tag: J5A53_RS13165
• Protein ID: WP_014845635.1
• Coordinates: 2924340..2924600 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: J5A53_RS13160
• Protein ID: WP_234028405.1
• Coordinates: 2924090..2924338 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5A53_RS13145 (J5A53_13145)	2919533..2920690	-	1158	WP_014845639.1	histidine kinase	-
J5A53_RS13150 (J5A53_13150)	2920687..2921730	-	1044	WP_051014908.1	alpha/beta hydrolase	-
J5A53_RS13155 (J5A53_13155)	2921797..2923728	-	1932	WP_041696138.1	serine hydrolase domain-containing protein	-
J5A53_RS13160 (J5A53_13160)	2924090..2924338	+	249	WP_234028405.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
J5A53_RS13165 (J5A53_13165)	2924340..2924600	+	261	WP_014845635.1	Txe/YoeB family addiction module toxin	Toxin
J5A53_RS13170 (J5A53_13170)	2924814..2925467	+	654	WP_014845634.1	peptide-methionine (S)-S-oxide reductase MsrA	-
J5A53_RS13175 (J5A53_13175)	2925563..2926546	+	984	WP_123823886.1	hypothetical protein	-
J5A53_RS13180 (J5A53_13180)	2926761..2927987	-	1227	WP_014845631.1	acetyl-CoA hydrolase/transferase C-terminal domain-containing protein	-
J5A53_RS13185 (J5A53_13185)	2927995..2928873	-	879	WP_014845630.1	neutral zinc metallopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-69)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10590.93 Da
• Isoelectric Point: 8.4729

>T197678 WP_014845635.1 NZ_CP072385:2924340-2924600 [Arachnia propionica]
MRICWADEAWEDYLWWQTQDRRTLKRINSLIRDIARNGNEELGKPEALRYQLSGYWSRRITEEHRLVYRITDTEVQIAAC
RYHYGR

Nucleotide

• Length: 261 bp

>T197678 NZ_CP096570:4234909-4235166 [Xanthomonas translucens pv. undulosa]
GTGACGCTTCAGTTCTCGGACAATGCCTGGGAGGACGACCTCTACTGGCAGCAAACCGACAAGAAGATGCTCAAGCGCGT
CAACGATCTGATCAAAGCCATTCAACGCGATCCCTTCCAAGGCGTCGGCAAGCCAGAACCGCTGCGCCATGCCTTGGCCG
GCTACTGGTCGCGGCGCATCAACGAAGAACACCGCATCGTGTACAGGGTCGAGGCGGGCATCCTGCTGATCGCGCAGGTG
CGCTACCACTATCTGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9281.27 Da
• Isoelectric Point: 4.3422

>AT197678 WP_234028405.1 NZ_CP072385:2924090-2924338 [Arachnia propionica]
MSYTESRANYAAVLDEVVNNREEIVITRAGHEPVVIVSLEEYQSLRETAYLLRSPANAQRLASAMEQLDRNDGIPHDLLD
DH

Nucleotide

• Length: 249 bp

>AT197678 NZ_CP096570:4234661-4234912 [Xanthomonas translucens pv. undulosa]
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTTGCGGACACCATGGAGCGCGTCGTCAACAACCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTTGAAGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTGCGCAGTCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTCGAGGCCGGTCGCGGCAAGGCACGGGAC
CTGGCCGAGTGA

Structures

Toxin

• AlphaFold DB: A0A3N4CWJ0