Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2844195..2844856 Replicon chromosome
Accession NZ_CP072384
Organism Arachnia rubra strain DSMZ 100122

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag J5A65_RS12930 Protein ID WP_223927598.1
Coordinates 2844195..2844545 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag J5A65_RS12935 Protein ID WP_212322765.1
Coordinates 2844551..2844856 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5A65_RS12915 (J5A65_12915) 2840091..2841386 + 1296 WP_212322753.1 histidine kinase -
J5A65_RS12920 (J5A65_12920) 2841545..2842345 + 801 WP_212322757.1 response regulator transcription factor -
J5A65_RS12925 (J5A65_12925) 2842413..2843648 - 1236 WP_212322759.1 beta-glucanase -
J5A65_RS12930 (J5A65_12930) 2844195..2844545 + 351 WP_223927598.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J5A65_RS12935 (J5A65_12935) 2844551..2844856 + 306 WP_212322765.1 helix-turn-helix transcriptional regulator Antitoxin
J5A65_RS12940 (J5A65_12940) 2845630..2845869 + 240 WP_212322767.1 antitoxin VbhA family protein -
J5A65_RS12945 (J5A65_12945) 2846472..2847392 - 921 WP_263407078.1 IS3 family transposase -
J5A65_RS12955 (J5A65_12955) 2847570..2848196 - 627 WP_212322772.1 winged helix-turn-helix domain-containing protein -
J5A65_RS12960 (J5A65_12960) 2848768..2849523 + 756 WP_212321357.1 transposase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2828294..2847308 19014


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(8-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13249.13 Da        Isoelectric Point: 6.4808

>T197670 WP_223927598.1 NZ_CP072384:2844195-2844545 [Arachnia rubra]
VDIELIADWLASLDDDSREQVVAAIELLEDRGPQLGRPIVDTVTSSRHRNMKELRPGSSGRSELRILFAFDPKRAAIMLI
AGNKAGNWVRWYKKNIPLADDLFDDHLRALRKVREE

Download         Length: 351 bp

>T197670 NZ_CP096540:c2042550-2042398 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11379.01 Da        Isoelectric Point: 8.5624

>AT197670 WP_212322765.1 NZ_CP072384:2844551-2844856 [Arachnia rubra]
MAMTLKDFLAENPVDRERVEAHKERMLTEVRAYHLRELREQAGLTQAQLAERIGVGQRQVSKIEHGHLDNAKVGTIRNYL
KAVGGSLALEYVVGDQRVQVA

Download         Length: 306 bp

>AT197670 NZ_CP096540:c2043174-2042575 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References