Detailed information of TA system TA197660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1211762..1212276
• Replicon: chromosome
• Accession: NZ_CP072377
• Organism: Leptotrichia sp. oral taxon 218 strain F0707

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: J5A73_RS05600
• Protein ID: WP_211613762.1
• Coordinates: 1211762..1212019 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: U2RIH6
• Locus tag: J5A73_RS05605
• Protein ID: WP_021766441.1
• Coordinates: 1212019..1212276 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5A73_RS05585 (J5A73_05585)	1207904..1208323	-	420	WP_256438629.1	transposase	-
J5A73_RS05590 (J5A73_05590)	1208450..1210240	-	1791	WP_211613757.1	tetratricopeptide repeat protein	-
J5A73_RS05595 (J5A73_05595)	1210263..1211411	-	1149	WP_211613760.1	hypothetical protein	-
J5A73_RS05600 (J5A73_05600)	1211762..1212019	-	258	WP_211613762.1	Txe/YoeB family addiction module toxin	Toxin
J5A73_RS05605 (J5A73_05605)	1212019..1212276	-	258	WP_021766441.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
J5A73_RS05610 (J5A73_05610)	1212597..1213985	+	1389	WP_211613764.1	MATE family efflux transporter	-
J5A73_RS05615 (J5A73_05615)	1214125..1214469	-	345	WP_211613766.1	hypothetical protein	-
J5A73_RS05620 (J5A73_05620)	1214606..1215859	-	1254	WP_211613768.1	ATP-binding protein	-
J5A73_RS05625 (J5A73_05625)	1215952..1216149	-	198	WP_249069479.1	AraC family transcriptional regulator	-
J5A73_RS10455	1216055..1216624	-	570	WP_249069501.1	hypothetical protein	-
J5A73_RS05630 (J5A73_05630)	1216630..1217121	-	492	WP_256438661.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10244.77 Da
• Isoelectric Point: 9.7289

>T197660 WP_211613762.1 NZ_CP072377:c1212019-1211762 [Leptotrichia sp. oral taxon 218]
MNLTWTDIAWGQYEEWQKQDKKIVKKINEIIKDIKRNGNERIGKPEPLKHELSGYWSRRITDKHRFIYKLTETSIVVIAC
ANHYE

Nucleotide

• Length: 258 bp

>T197660 NZ_CP096535:c2181045-2180836 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9986.26 Da
• Isoelectric Point: 4.6535

>AT197660 WP_021766441.1 NZ_CP072377:c1212276-1212019 [Leptotrichia sp. oral taxon 218]
MIATNYSNVRNNLKKYCDKATDDYETVIITRKNDKNVVLMSEEEYNNLMENLYIMSNKKYYNELLKSKAEAEAGNVQIHD
IIEVE

Nucleotide

• Length: 258 bp

>AT197660 NZ_CP096535:c2181350-2181057 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: U2RIH6