Detailed information of TA system TA197461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2208041..2208575
• Replicon: chromosome
• Accession: NZ_CP072172
• Organism: Rhizobium sp. AB2/73

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: J5284_RS10850
• Protein ID: WP_083258170.1
• Coordinates: 2208309..2208575 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1E4YBJ2
• Locus tag: J5284_RS10845
• Protein ID: WP_069612752.1
• Coordinates: 2208041..2208301 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5284_RS10810 (J5284_10815)	2203534..2204241	+	708	WP_069612759.1	DUF1045 domain-containing protein	-
J5284_RS10815 (J5284_10820)	2204358..2205281	+	924	WP_069612758.1	allantoinase PuuE	-
J5284_RS10820 (J5284_10825)	2205283..2205780	+	498	WP_069612757.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
J5284_RS10825 (J5284_10830)	2206009..2206371	+	363	WP_069612756.1	DUF86 domain-containing protein	-
J5284_RS10830 (J5284_10835)	2206379..2206879	+	501	WP_069612755.1	ureidoglycolate lyase	-
J5284_RS10835 (J5284_10840)	2206876..2207232	+	357	WP_069612754.1	hydroxyisourate hydrolase	-
J5284_RS10840 (J5284_10845)	2207235..2207975	+	741	WP_069612753.1	metallophosphoesterase family protein	-
J5284_RS10845 (J5284_10850)	2208041..2208301	+	261	WP_069612752.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
J5284_RS10850 (J5284_10855)	2208309..2208575	+	267	WP_083258170.1	Txe/YoeB family addiction module toxin	Toxin
J5284_RS10855 (J5284_10860)	2208572..2209711	-	1140	WP_069612751.1	alpha-hydroxy acid oxidase	-
J5284_RS10860 (J5284_10865)	2209759..2211066	-	1308	WP_069612750.1	guanine deaminase	-
J5284_RS10865 (J5284_10870)	2211063..2212301	-	1239	WP_069612749.1	urate hydroxylase PuuD	-
J5284_RS10870 (J5284_10875)	2212515..2212850	+	336	WP_069612748.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10807.46 Da
• Isoelectric Point: 9.9059

>T197461 WP_083258170.1 NZ_CP072172:2208309-2208575 [Rhizobium sp. AB2/73]
MLLAWHAHAWEDYLYWRERDRKIAVRINELLRDALRHPFEGLGKPEALRNQLKGQWSRRITQEHRLIYKVEGEGDRQILI
VLQCRFHY

Nucleotide

• Length: 267 bp

>T197461 NZ_CP096200:c1048783-1048487 [Vibrio sinaloensis]
ATGCAAAAGAATAAATACAAACTAAGTAAATTGGCTCAGGCTCATTTACGAAAAATTAAAAGTTATACCGTCAATAACTT
TTCTGAAATGCAGTGGAACAACTATAAAGATACATTGCTAACTGGGTTTCAAATGCTCGCCGATAATCCAGCCGTAGGTC
GCAGTTGCGATGAGATTTATCCAAGCGGCTTCTTTTTTCCGGTAGGAAAACACACAGCTTACTTTACAAAAGAAGACGGT
TTTATTTTAGTTGTGGCTGTACTTGGTCAATCACAACTCCCACAAAACCACTTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9557.92 Da
• Isoelectric Point: 4.5084

>AT197461 WP_069612752.1 NZ_CP072172:2208041-2208301 [Rhizobium sp. AB2/73]
MRTVMFSAARNELASLLDEVVQDRVAVEIVRRDKPSAILIDKEEYEGIIETLHVLSTPANAARLMEAITDANEGKNLVSH
DLIDPK

Nucleotide

• Length: 261 bp

>AT197461 NZ_CP096200:c1049032-1048790 [Vibrio sinaloensis]
ATGCACACACTAACAGCAAATGATGCAAAGCGTAACTTTGGTGAGTTGCTTCTAAGCGCCCAACGTGAGCCAGTAAAGAT
TAGCAAAAACAGTAAAGATGCCGTAGTGGTAATGTCTATCAAAGACTATGAAGAACTAGAGGCAATGAAAACTGATTACC
TTAAACATTGTTTCGAGTCGGCTAAACAAGACTTAGCACAAGGCAATGTAGTTGATGGTGAAGATTTCCTAAGCGCCTTG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A1E4YBJ2